Regulation of G protein-coupled receptor export trafficking

Chunmin Dong, Catalin M. Filipeanu, Matthew T. Duvernay, Guangyu Wu

Research output: Contribution to journalReview article

182 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors which share a common topology of seven transmembrane domains and modulate a variety of cell functions through coupling to heterotrimeric G proteins by responding to a vast array of stimuli. The magnitude of cellular response elicited by a given signal is dictated by the level of GPCR expression at the plasma membrane, which is the balance of elaborately regulated endocytic and exocytic trafficking. This review will cover recent advances in understanding the molecular mechanism underlying anterograde transport of the newly synthesized GPCRs from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane. We will focus on recently identified motifs involved in GPCR exit from the ER and the Golgi, GPCR folding in the ER and the rescue of misfolded receptors from within, GPCR-interacting proteins that modulate receptor cell-surface targeting, pathways that mediate GPCR traffic, and the functional role of export in controlling GPCR signaling.

Original languageEnglish (US)
Pages (from-to)853-870
Number of pages18
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1768
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

Keywords

  • Biosynthesis
  • Chemical chaperone
  • ER chaperone
  • ER export motif
  • ER retention motif
  • Endoplasmic reticulum
  • Export
  • Folding
  • G protein-coupled receptor
  • GPCR-interacting protein
  • Golgi
  • Intracellular trafficking
  • Pharmacological chaperone
  • Signal transduction
  • Sorting and targeting

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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