Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala

Heterosynaptic induction mechanisms of late-LTP

Sabine Frey, Jorge Bergado-Rosado, Thomas Seidenbecher, Hans Christian Pape, J. Uwe Frey

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and β-adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.

Original languageEnglish (US)
Pages (from-to)3697-3703
Number of pages7
JournalJournal of Neuroscience
Volume21
Issue number10
StatePublished - May 15 2001

Fingerprint

Long-Term Potentiation
Dentate Gyrus
Maintenance
Perforant Pathway
Adrenergic Agents
Basolateral Nuclear Complex
Reinforcement (Psychology)
Learning

Keywords

  • Associative LTP
  • Basolateral amygdala
  • Dentate gyrus
  • Heterosynaptic LTP
  • Hippocampus
  • Late-LTP
  • Long-term potentiation
  • Reinforcement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala : Heterosynaptic induction mechanisms of late-LTP. / Frey, Sabine; Bergado-Rosado, Jorge; Seidenbecher, Thomas; Pape, Hans Christian; Frey, J. Uwe.

In: Journal of Neuroscience, Vol. 21, No. 10, 15.05.2001, p. 3697-3703.

Research output: Contribution to journalArticle

Frey, Sabine ; Bergado-Rosado, Jorge ; Seidenbecher, Thomas ; Pape, Hans Christian ; Frey, J. Uwe. / Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala : Heterosynaptic induction mechanisms of late-LTP. In: Journal of Neuroscience. 2001 ; Vol. 21, No. 10. pp. 3697-3703.
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