Reinforcement of rat hippocampal LTP by holeboard training

Shukhrat Uzakov, Julietta U. Frey, Volker Korz

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be transformed (reinforced) into late-LTP by the association of arousing novel environmental stimuli. Here we show that consolidation of spatial memory also reinforces early-LTP in the dentate gyrus. Both memory consolidation and LTP-reinforcement depend on protein synthesis. Four groups of animals were trained by five, seven, eight or 10 trials, respectively, to recognize a fixed pattern of baited holes. The last trial was performed 15 min after tetanus. Errors of long-term reference memory during the last trial were significantly decreased only in the eight- and 10-trial experimental groups compared to pseudo-trained animals. In correlation to this learning effect we found a reinforcement of early-LTP only in these experimental groups compared to controls. The data suggest that the synthesis of new proteins required for spatial reference-memory formation also contributes to LTP maintenance in the hippocampal dentate gyrus.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalLearning and Memory
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2005

Fingerprint

Long-Term Potentiation
Dentate Gyrus
Proteins
Reinforcement (Psychology)
Parahippocampal Gyrus
Long-Term Memory
Tetanus
Maintenance
Learning

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Reinforcement of rat hippocampal LTP by holeboard training. / Uzakov, Shukhrat; Frey, Julietta U.; Korz, Volker.

In: Learning and Memory, Vol. 12, No. 2, 01.03.2005, p. 165-171.

Research output: Contribution to journalArticle

Uzakov, Shukhrat ; Frey, Julietta U. ; Korz, Volker. / Reinforcement of rat hippocampal LTP by holeboard training. In: Learning and Memory. 2005 ; Vol. 12, No. 2. pp. 165-171.
@article{bdb628977c68455eaa28985f580d4d12,
title = "Reinforcement of rat hippocampal LTP by holeboard training",
abstract = "Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be transformed (reinforced) into late-LTP by the association of arousing novel environmental stimuli. Here we show that consolidation of spatial memory also reinforces early-LTP in the dentate gyrus. Both memory consolidation and LTP-reinforcement depend on protein synthesis. Four groups of animals were trained by five, seven, eight or 10 trials, respectively, to recognize a fixed pattern of baited holes. The last trial was performed 15 min after tetanus. Errors of long-term reference memory during the last trial were significantly decreased only in the eight- and 10-trial experimental groups compared to pseudo-trained animals. In correlation to this learning effect we found a reinforcement of early-LTP only in these experimental groups compared to controls. The data suggest that the synthesis of new proteins required for spatial reference-memory formation also contributes to LTP maintenance in the hippocampal dentate gyrus.",
author = "Shukhrat Uzakov and Frey, {Julietta U.} and Volker Korz",
year = "2005",
month = "3",
day = "1",
doi = "10.1101/lm.89305",
language = "English (US)",
volume = "12",
pages = "165--171",
journal = "Learning and Memory",
issn = "1072-0502",
publisher = "Cold Spring Harbor Laboratory Press",
number = "2",

}

TY - JOUR

T1 - Reinforcement of rat hippocampal LTP by holeboard training

AU - Uzakov, Shukhrat

AU - Frey, Julietta U.

AU - Korz, Volker

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be transformed (reinforced) into late-LTP by the association of arousing novel environmental stimuli. Here we show that consolidation of spatial memory also reinforces early-LTP in the dentate gyrus. Both memory consolidation and LTP-reinforcement depend on protein synthesis. Four groups of animals were trained by five, seven, eight or 10 trials, respectively, to recognize a fixed pattern of baited holes. The last trial was performed 15 min after tetanus. Errors of long-term reference memory during the last trial were significantly decreased only in the eight- and 10-trial experimental groups compared to pseudo-trained animals. In correlation to this learning effect we found a reinforcement of early-LTP only in these experimental groups compared to controls. The data suggest that the synthesis of new proteins required for spatial reference-memory formation also contributes to LTP maintenance in the hippocampal dentate gyrus.

AB - Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be transformed (reinforced) into late-LTP by the association of arousing novel environmental stimuli. Here we show that consolidation of spatial memory also reinforces early-LTP in the dentate gyrus. Both memory consolidation and LTP-reinforcement depend on protein synthesis. Four groups of animals were trained by five, seven, eight or 10 trials, respectively, to recognize a fixed pattern of baited holes. The last trial was performed 15 min after tetanus. Errors of long-term reference memory during the last trial were significantly decreased only in the eight- and 10-trial experimental groups compared to pseudo-trained animals. In correlation to this learning effect we found a reinforcement of early-LTP only in these experimental groups compared to controls. The data suggest that the synthesis of new proteins required for spatial reference-memory formation also contributes to LTP maintenance in the hippocampal dentate gyrus.

UR - http://www.scopus.com/inward/record.url?scp=17144424603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144424603&partnerID=8YFLogxK

U2 - 10.1101/lm.89305

DO - 10.1101/lm.89305

M3 - Article

C2 - 15774946

AN - SCOPUS:17144424603

VL - 12

SP - 165

EP - 171

JO - Learning and Memory

JF - Learning and Memory

SN - 1072-0502

IS - 2

ER -