Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

Queen Henry-Okafor, Sean P. Collins, Cathy A. Jenkins, Karen F. Miller, David J. Maron, Allen J. Naftilan, Neal Weintraub, Gregory J. Fermann, John Mcpherson, Santosh Menon, Douglas B. Sawyer, Alan B. Storrow

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6 Scopus citations

Abstract

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalOpen Biomarkers Journal
Volume5
Issue number1
DOIs
Publication statusPublished - Aug 22 2012

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Keywords

  • Acute heart failure
  • B-type natriuretic peptide
  • Prognostic outcomes
  • Uric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Henry-Okafor, Q., Collins, S. P., Jenkins, C. A., Miller, K. F., Maron, D. J., Naftilan, A. J., ... Storrow, A. B. (2012). Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure. Open Biomarkers Journal, 5(1), 9-15. https://doi.org/10.2174/1875318301205010009