Relationship between uric acid levels and diagnostic and prognostic outcomes in acute heart failure

Queen Henry-Okafor, Sean P. Collins, Cathy A. Jenkins, Karen F. Miller, David J. Maron, Allen J. Naftilan, Neal Weintraub, Gregory J. Fermann, John Mcpherson, Santosh Menon, Douglas B. Sawyer, Alan B. Storrow

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses. Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results. Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalOpen Biomarkers Journal
Volume5
Issue number1
DOIs
StatePublished - 2012

Keywords

  • Acute heart failure
  • B-type natriuretic peptide
  • Prognostic outcomes
  • Uric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Biochemistry
  • Biochemistry, medical

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