Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Anna Liza B. Valiña-Tóth, Zongshan Lai, Wonsuk Yoo, Abdul Abou-Samra, Crystal A. Gadegbeku, John M. Flack

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. Design A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. Results Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0·02), truncal (P = 0·03) and extremity (P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0·02). Total fat mass in groups 1-3, respectively, was 30·0, 34·0 and 37·4 kg (P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg (P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg (P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
JournalClinical Endocrinology
Volume72
Issue number5
DOIs
StatePublished - May 1 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans'. Together they form a unique fingerprint.

  • Cite this

    Valiña-Tóth, A. L. B., Lai, Z., Yoo, W., Abou-Samra, A., Gadegbeku, C. A., & Flack, J. M. (2010). Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. Clinical Endocrinology, 72(5), 595-603. https://doi.org/10.1111/j.1365-2265.2009.03676.x