Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Anna Liza B. Valiña-Tóth, Zongshan Lai, Wonsuk Yoo, Abdul Abou-Samra, Crystal A. Gadegbeku, John M. Flack

Research output: Contribution to journalArticle

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Abstract

Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. Design A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. Results Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0·02), truncal (P = 0·03) and extremity (P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0·02). Total fat mass in groups 1-3, respectively, was 30·0, 34·0 and 37·4 kg (P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg (P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg (P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
JournalClinical Endocrinology
Volume72
Issue number5
DOIs
StatePublished - May 1 2010

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Body Composition
Parathyroid Hormone
Vitamin D
African Americans
Obesity
Fats
Body Size
Linear Models
National Institute of Environmental Health Sciences (U.S.)
Extremities
Regression Analysis
Photon Absorptiometry
Weight Loss
Salts
Cross-Sectional Studies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Valiña-Tóth, A. L. B., Lai, Z., Yoo, W., Abou-Samra, A., Gadegbeku, C. A., & Flack, J. M. (2010). Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. Clinical Endocrinology, 72(5), 595-603. https://doi.org/10.1111/j.1365-2265.2009.03676.x

Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. / Valiña-Tóth, Anna Liza B.; Lai, Zongshan; Yoo, Wonsuk; Abou-Samra, Abdul; Gadegbeku, Crystal A.; Flack, John M.

In: Clinical Endocrinology, Vol. 72, No. 5, 01.05.2010, p. 595-603.

Research output: Contribution to journalArticle

Valiña-Tóth, ALB, Lai, Z, Yoo, W, Abou-Samra, A, Gadegbeku, CA & Flack, JM 2010, 'Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans', Clinical Endocrinology, vol. 72, no. 5, pp. 595-603. https://doi.org/10.1111/j.1365-2265.2009.03676.x
Valiña-Tóth, Anna Liza B. ; Lai, Zongshan ; Yoo, Wonsuk ; Abou-Samra, Abdul ; Gadegbeku, Crystal A. ; Flack, John M. / Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. In: Clinical Endocrinology. 2010 ; Vol. 72, No. 5. pp. 595-603.
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