Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura

Cindy E. Neunert, George R. Buchanan, Victor Blanchette, Dorothy Barnard, Nancy L. Young, Christine Curtis, Robert J. Klaassen

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Important outcomes for children with immune thrombocytopenic purpura (ITP) include health-related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined.

Original languageEnglish (US)
Pages (from-to)652-654
Number of pages3
JournalPediatric Blood and Cancer
Volume53
Issue number4
DOIs
StatePublished - Oct 1 2009

Keywords

  • Bleeding severity
  • ITP
  • Quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Neunert, C. E., Buchanan, G. R., Blanchette, V., Barnard, D., Young, N. L., Curtis, C., & Klaassen, R. J. (2009). Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura. Pediatric Blood and Cancer, 53(4), 652-654. https://doi.org/10.1002/pbc.21978