TY - JOUR
T1 - Relationships between reverse transcriptase-polymerase chain reaction for prostate specific antigen, survival, and various prognostic laboratory factors in patients with hormone refractory prostate cancer
AU - Gandhok, Navjeet K.
AU - Looney, Stephen
AU - Koochekpour, Shahriar
AU - Sartor, Oliver
PY - 2005/5
Y1 - 2005/5
N2 - The detection of prostate-specific antigen (PSA) mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) in the bloodstream of prostate cancer patients has been hypothesized as a prognostic marker, however little data are available concerning the association between this molecular marker and other laboratory values of potential importance. In this study, in patients with hormone-refractory prostate cancer (HRPC), relationships were determined between PSA RT-PCR positivity, survival, and various relevant markers including serum PSA, LDH, albumin, alkaline phosphatase and hemoglobin. A total of 19/30 HRPC patients were positive for PSA by RT-PCR. Positivity was significantly linked to serum PSA (P = 0.004) and serum alkaline phosphatase (P = 0.026) but not to the other laboratory variables. Median survival time for RT-PCR-positive patients was 9 months, compared to 19 months for RT-PCR-negative patients (P = 0.035). Median survival time for patients with a hemoglobin ≥11 g/dL was 12 months, compared to 9 months for patients with <11 g/dL (P = 0.005). Dichotomized (≥ or < median) serum PSA, LDH, alkaline phosphatase, and albumin were not significantly associated with survival in univariate analyses. In multivariate analysis, only dichotomized hemoglobin (<11g/dL vs. ≥11g/dL) remained statistically significant (P = 0.019), indicating that RT-PCR had no independent association with survival after controlling for hemoglobin status in this study.
AB - The detection of prostate-specific antigen (PSA) mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) in the bloodstream of prostate cancer patients has been hypothesized as a prognostic marker, however little data are available concerning the association between this molecular marker and other laboratory values of potential importance. In this study, in patients with hormone-refractory prostate cancer (HRPC), relationships were determined between PSA RT-PCR positivity, survival, and various relevant markers including serum PSA, LDH, albumin, alkaline phosphatase and hemoglobin. A total of 19/30 HRPC patients were positive for PSA by RT-PCR. Positivity was significantly linked to serum PSA (P = 0.004) and serum alkaline phosphatase (P = 0.026) but not to the other laboratory variables. Median survival time for RT-PCR-positive patients was 9 months, compared to 19 months for RT-PCR-negative patients (P = 0.035). Median survival time for patients with a hemoglobin ≥11 g/dL was 12 months, compared to 9 months for patients with <11 g/dL (P = 0.005). Dichotomized (≥ or < median) serum PSA, LDH, alkaline phosphatase, and albumin were not significantly associated with survival in univariate analyses. In multivariate analysis, only dichotomized hemoglobin (<11g/dL vs. ≥11g/dL) remained statistically significant (P = 0.019), indicating that RT-PCR had no independent association with survival after controlling for hemoglobin status in this study.
KW - Hormone refractory prostate cancer
KW - PSA-mRNA
KW - Prognosis
KW - RT-PCR
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=19344363332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19344363332&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2004.11.009
DO - 10.1016/j.urolonc.2004.11.009
M3 - Article
C2 - 15907715
AN - SCOPUS:19344363332
SN - 1078-1439
VL - 23
SP - 163
EP - 167
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 3
ER -