Relationships between total and allergen-specific serum IgE concentrations and lung function in young adults

Chathruckan Rajendra, Edward Zoratti, Suzanne Havstad, Charlotte Nicholas, Ganesa Wegienka, M. Todd Cross, Christine C. Johnson, Dennis Randall Ownby

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Prior studies have shown relationships between serum immunoglobulin E (IgE) and asthma. Objective: To investigate relationships between total and allergen-specific IgE concentrations and lung function in young adults. Methods: Measurements of total IgE, allergen-specific IgE to 6 common allergens, and spirometry (forced expiratory volume in one second [FEV 1], forced vital capacity [FVC], FEV 1/FVC, and percent change in FEV 1 after bronchodilation) were used to calculate correlations between the logarithmically transformed IgE values and measures of lung function among participants in a birth cohort not selected for risk of allergic disease stratified by current asthma, prior asthma, or no asthma. Results: The 428 participants were 51.6% female, 93% white, and 18.4 (standard deviation = 0.6) years old. Forty-eight (11.2%) had current asthma, 55 (12.9%) had a history of asthma, and 325 (75.9%) never had asthma. For males with current asthma, correlations between total IgE and FEV 1% and FVC% were -0.51 (P =.06) and -0.70 (P =.005), respectively. For females with current asthma, the only significant correlation was between total IgE and the FEV 1/FVC ratio (-0.55, P =.001). After excluding smokers and individuals without detectable allergen-specific IgE, the negative correlations for both males and females remained statistically significant. The correlations among males or females with prior asthma or no history of asthma were minimal and not statistically significant. The sum of the allergen-specific IgEs showed the same pattern of relationships to lung function as did total IgE. Conclusion: Our results show significant negative correlations that vary by gender between both total and allergen-specific IgE and measurements of lung function in young adults with current asthma.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalAnnals of Allergy, Asthma and Immunology
Volume108
Issue number6
DOIs
StatePublished - Jun 1 2012

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Allergens
Immunoglobulin E
Young Adult
Asthma
Lung
Serum
Vital Capacity
Spirometry
Forced Expiratory Volume
Parturition

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Relationships between total and allergen-specific serum IgE concentrations and lung function in young adults. / Rajendra, Chathruckan; Zoratti, Edward; Havstad, Suzanne; Nicholas, Charlotte; Wegienka, Ganesa; Cross, M. Todd; Johnson, Christine C.; Ownby, Dennis Randall.

In: Annals of Allergy, Asthma and Immunology, Vol. 108, No. 6, 01.06.2012, p. 429-434.

Research output: Contribution to journalArticle

Rajendra, Chathruckan ; Zoratti, Edward ; Havstad, Suzanne ; Nicholas, Charlotte ; Wegienka, Ganesa ; Cross, M. Todd ; Johnson, Christine C. ; Ownby, Dennis Randall. / Relationships between total and allergen-specific serum IgE concentrations and lung function in young adults. In: Annals of Allergy, Asthma and Immunology. 2012 ; Vol. 108, No. 6. pp. 429-434.
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AU - Zoratti, Edward

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AU - Cross, M. Todd

AU - Johnson, Christine C.

AU - Ownby, Dennis Randall

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AB - Background: Prior studies have shown relationships between serum immunoglobulin E (IgE) and asthma. Objective: To investigate relationships between total and allergen-specific IgE concentrations and lung function in young adults. Methods: Measurements of total IgE, allergen-specific IgE to 6 common allergens, and spirometry (forced expiratory volume in one second [FEV 1], forced vital capacity [FVC], FEV 1/FVC, and percent change in FEV 1 after bronchodilation) were used to calculate correlations between the logarithmically transformed IgE values and measures of lung function among participants in a birth cohort not selected for risk of allergic disease stratified by current asthma, prior asthma, or no asthma. Results: The 428 participants were 51.6% female, 93% white, and 18.4 (standard deviation = 0.6) years old. Forty-eight (11.2%) had current asthma, 55 (12.9%) had a history of asthma, and 325 (75.9%) never had asthma. For males with current asthma, correlations between total IgE and FEV 1% and FVC% were -0.51 (P =.06) and -0.70 (P =.005), respectively. For females with current asthma, the only significant correlation was between total IgE and the FEV 1/FVC ratio (-0.55, P =.001). After excluding smokers and individuals without detectable allergen-specific IgE, the negative correlations for both males and females remained statistically significant. The correlations among males or females with prior asthma or no history of asthma were minimal and not statistically significant. The sum of the allergen-specific IgEs showed the same pattern of relationships to lung function as did total IgE. Conclusion: Our results show significant negative correlations that vary by gender between both total and allergen-specific IgE and measurements of lung function in young adults with current asthma.

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