Relaxation of rat tail artery to electrical stimulation

Anthony B. Ebeigbe, Robin D. Gantzos, R Clinton Webb

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Rat tail artery strips relax in response to electrical stimulation (0.1-8Hz, 9V, 1.0msec) following contraction induced by norepinephrine (5.9xl0−7M). The relaxation is not altered by treatment of the strips with atropine, propranolol, tetrodotoxin or indomethacin nor by chemical denervation with 6-hydroxydopamine. Incubation of strips in calcium-free solution reduced the contractile response to norepinephrine and blocked relaxation in response to 4Hz electrical stimulation. Histamine antagonists (H2 receptor subclass: Cimetidine, metiamide) inhibited the relaxation to electrical stimulation in a dose-dependent manner. These results suggest that relaxation to electrical stimulation in rat tail artery is modulated by calcium and by the H2 subclass of histamine receptors.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalLife sciences
Volume33
Issue number4
DOIs
StatePublished - Jan 1 1983

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Electric Stimulation
Tail
Rats
Norepinephrine
Arteries
Metiamide
Histamine H2 Antagonists
Calcium
Histamine H2 Receptors
Oxidopamine
Cimetidine
Tetrodotoxin
Atropine
Propranolol
Indomethacin
Denervation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Relaxation of rat tail artery to electrical stimulation. / Ebeigbe, Anthony B.; Gantzos, Robin D.; Webb, R Clinton.

In: Life sciences, Vol. 33, No. 4, 01.01.1983, p. 303-309.

Research output: Contribution to journalArticle

Ebeigbe, Anthony B. ; Gantzos, Robin D. ; Webb, R Clinton. / Relaxation of rat tail artery to electrical stimulation. In: Life sciences. 1983 ; Vol. 33, No. 4. pp. 303-309.
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