Renal excretory responses of taurine-depleted rats to hypotonic and hypertonic saline infusion

Mahmood S Mozaffari, B. K. Warren, J. Azuma, S. W. Schaffer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Male Wistar-Kyoto rats were given either tap water (control) or 3% β-alanine (taurine-depleted) for three weeks. To prepare for the kidney function studies, the animals were then implanted with femoral vessels and bladder catheters. Two days after surgery, each rat was given an intravenous infusion of saline at the rate of 50 μl/min and urine samples were collected at specific time intervals. An isotonic saline solution (0.9% NaCl) was infused for determination of baseline parameters and was followed by the infusion of a hypotonic saline solution (0.45% NaCl). Two days later, the infusion protocol was repeated in the same animals; however, a hypertonic saline solution (1.8% NaCl) was substituted for the hypotonic saline solution. Renal excretion of fluid and sodium increased in the control, but not taurine-depleted, rats during the hypotonic saline infusion. Interestingly, diuretic and natriuretic responses were similar between the groups during hypertonic saline infusion. The results suggest that taurine-depletion in rats affects renal excretory responses to a hypotonic, but not a hypertonic, saline solution.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalAmino Acids
Volume15
Issue number1-2
DOIs
StatePublished - Oct 9 1998

Fingerprint

Taurine
Hypertonic Saline Solutions
Sodium Chloride
Hypotonic Solutions
Rats
Kidney
Isotonic Solutions
Animals
Inbred WKY Rats
Thigh
Ambulatory Surgical Procedures
Diuretics
Intravenous Infusions
Alanine
Catheters
Urinary Bladder
Sodium
Urine
Surgery
Water

Keywords

  • Amino acids
  • Hypertonic saline
  • Hypotonic saline
  • Natriuresis
  • Rat
  • Taurine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Renal excretory responses of taurine-depleted rats to hypotonic and hypertonic saline infusion. / Mozaffari, Mahmood S; Warren, B. K.; Azuma, J.; Schaffer, S. W.

In: Amino Acids, Vol. 15, No. 1-2, 09.10.1998, p. 109-116.

Research output: Contribution to journalArticle

Mozaffari, Mahmood S ; Warren, B. K. ; Azuma, J. ; Schaffer, S. W. / Renal excretory responses of taurine-depleted rats to hypotonic and hypertonic saline infusion. In: Amino Acids. 1998 ; Vol. 15, No. 1-2. pp. 109-116.
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