Renoprotective approaches and strategies in acute kidney injury

Yuan Yang, Meifang Song, Yu Liu, Hong Liu, Lin Sun, Youming Peng, Fuyou Liu, Manjeri A. Venkatachalam, Zheng Dong

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and increasing prevalence. Decades of research have suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.

Original languageEnglish (US)
Pages (from-to)58-73
Number of pages16
JournalPharmacology and Therapeutics
Volume163
DOIs
StatePublished - Jul 1 2016

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Keywords

  • Acute kidney injury
  • Ischemia-reperfusion
  • Kidney protection
  • Kidney repair
  • Nephrotoxicity
  • Renoprotection

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Yang, Y., Song, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A., & Dong, Z. (2016). Renoprotective approaches and strategies in acute kidney injury. Pharmacology and Therapeutics, 163, 58-73. https://doi.org/10.1016/j.pharmthera.2016.03.015