Reproducibility of p3

Edward Y. Zamrini; Kimford J. Meador; William O. Thompson; Gregory P. Lee

doi:10.3109/00207459108986279

Reproducibility of p3

Edward Y. Zamrini, Kimford J. Meador, William O. Thompson, Gregory P. Lee

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 μV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was ±20 ms for latency and ±4.63 μV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.

Original language	English (US)
Pages (from-to)	113-120
Number of pages	8
Journal	International Journal of Neuroscience
Volume	61
Issue number	1-2
DOIs	https://doi.org/10.3109/00207459108986279
State	Published - 1991
Externally published	Yes

Keywords

Auditory
Evoked potentials
Human

ASJC Scopus subject areas

Neuroscience(all)

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10.3109/00207459108986279

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@article{a78c77d9bf4c41a087ccd2e0fb90266e,

title = "Reproducibility of p3",

abstract = "The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 μV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was ±20 ms for latency and ±4.63 μV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.",

keywords = "Auditory, Evoked potentials, Human",

author = "Zamrini, {Edward Y.} and Meador, {Kimford J.} and Thompson, {William O.} and Lee, {Gregory P.}",

note = "Funding Information: The study was supported in part by the Medical Research Service of the Department of Veterans Affairs, and by Merrell Dow Research Institute. The authors would like to thank Dr. M. Rivner and Miss E. Thompson for assistance in computer data management and to P. Turner for preparation of the manuscript. Dr. Meador is recipient of NIH/NIA Clinical Investigator Award #1K08 AGO03 14.",

year = "1991",

doi = "10.3109/00207459108986279",

language = "English (US)",

volume = "61",

pages = "113--120",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Informa Healthcare",

number = "1-2",

}

TY - JOUR

T1 - Reproducibility of p3

AU - Zamrini, Edward Y.

AU - Meador, Kimford J.

AU - Thompson, William O.

AU - Lee, Gregory P.

N1 - Funding Information: The study was supported in part by the Medical Research Service of the Department of Veterans Affairs, and by Merrell Dow Research Institute. The authors would like to thank Dr. M. Rivner and Miss E. Thompson for assistance in computer data management and to P. Turner for preparation of the manuscript. Dr. Meador is recipient of NIH/NIA Clinical Investigator Award #1K08 AGO03 14.

PY - 1991

Y1 - 1991

N2 - The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 μV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was ±20 ms for latency and ±4.63 μV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.

AB - The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 μV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was ±20 ms for latency and ±4.63 μV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.

KW - Auditory

KW - Evoked potentials

KW - Human

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SP - 113

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JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 1-2

ER -

Reproducibility of p3

Abstract

Keywords

ASJC Scopus subject areas

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