Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages - A potential therapeutic approach

Meenakshi Ahluwalia, Manish Kumar, Pankaj Ahluwalia, Scott Rahimi, John R. Vender, Raghavan P. Raju, David C. Hess, Babak Baban, Fernando L. Vale, Krishnan M. Dhandapani, Kumar Vaibhav

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondria are dynamic organelles responsible for cellular energy production. Besides, regulating energy homeostasis, mitochondria are responsible for calcium homeostasis, signal transmission, and the fate of cellular survival in case of injury and pathologies. Accumulating reports have suggested multiple roles of mitochondria in neuropathologies, neurodegeneration, and immune activation under physiological and pathological conditions. Mitochondrial dysfunction, which occurs at the initial phase of brain injury, involves oxidative stress, inflammation, deficits in mitochondrial bioenergetics, biogenesis, transport, and autophagy. Thus, development of targeted therapeutics to protect mitochondria may improve functional outcomes following traumatic brain injury (TBI) and intracerebral hemorrhages (ICH). In this review, we summarize mitochondrial dysfunction related to TBI and ICH, including the mechanisms involved, and discuss therapeutic approaches with special emphasis on past and current clinical trials.

Original languageEnglish (US)
Article number105192
JournalNeurochemistry International
Volume150
DOIs
StatePublished - Nov 2021

Keywords

  • Brain injury
  • Immune activation
  • Mitochondrial bioenergetics
  • Mitochondrial biogenesis
  • Mitophagy
  • Therapeutic approach

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Fingerprint

Dive into the research topics of 'Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages - A potential therapeutic approach'. Together they form a unique fingerprint.

Cite this