Research resource: DkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Consortium Interconnectivity Network: A pilot program to aggregate research resources generated by multiple research consortia

Neil J. McKenna, Christopher L. Howard, Michael Aufiero, Jeremy Easton-Marks, David L. Steffen, Lauren B. Becnel, Mark A. Magnuson, Richard A. McIndoe, Jean Philippe Cartailler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) supports multiple basic science consortia that generate high-content datasets, reagent resources, and methodologies, in the fields of kidney, urology, hematology, digestive, and endocrine diseases, as well as metabolic diseases such as diabetes and obesity. These currently include the Beta Cell Biology Consortium, the Nuclear Receptor Signaling Atlas, the Diabetic Complications Consortium, and the Mouse Metabolic Phenotyping Centers. Recognizing the synergy that would accrue from aggregating information generated and curated by these initiatives in a contiguous informatics network, we created the NIDDK Consortium Interconnectivity Network (dkCOIN; www.dkcoin.org). The goal of this pilot project, organized by the NIDDK, was to establish a single point of access to a toolkit of interconnected resources (datasets, reagents, and protocols) generated from individual consortia that could be readily accessed by biologists of diverse backgrounds and research interests. During the pilot phase of this activity dkCOIN collected nearly 2000 consortium-curated resources, including datasets (functional genomics) and reagents (mouse strains, antibodies, and adenoviral constructs) and built nearly 3000 resource-to-resource connections, thereby demonstrating the feasibility of further extending this database in the future. Thus, dkCOIN promises to be a useful informatics solution for rapidly identifying useful resources generated by participating research consortia.

Original languageEnglish (US)
Pages (from-to)1675-1681
Number of pages7
JournalMolecular Endocrinology
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2012

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National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Informatics
Research
Endocrine System Diseases
Atlases
Metabolic Diseases
Urology
Hematology
Diabetes Complications
Cytoplasmic and Nuclear Receptors
Genomics
Cell Biology
Obesity
Databases
Kidney
Antibodies
Datasets

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Research resource : DkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Consortium Interconnectivity Network: A pilot program to aggregate research resources generated by multiple research consortia. / McKenna, Neil J.; Howard, Christopher L.; Aufiero, Michael; Easton-Marks, Jeremy; Steffen, David L.; Becnel, Lauren B.; Magnuson, Mark A.; McIndoe, Richard A.; Cartailler, Jean Philippe.

In: Molecular Endocrinology, Vol. 26, No. 10, 01.10.2012, p. 1675-1681.

Research output: Contribution to journalArticle

McKenna, Neil J. ; Howard, Christopher L. ; Aufiero, Michael ; Easton-Marks, Jeremy ; Steffen, David L. ; Becnel, Lauren B. ; Magnuson, Mark A. ; McIndoe, Richard A. ; Cartailler, Jean Philippe. / Research resource : DkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Consortium Interconnectivity Network: A pilot program to aggregate research resources generated by multiple research consortia. In: Molecular Endocrinology. 2012 ; Vol. 26, No. 10. pp. 1675-1681.
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