Retinal Gangliosides in RCS Mutant Rats

Thomas N. Seyfried, Robert K. Yu, Nobuko Miyazawa, Yin‐Lok ‐L Lai

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Abstract

Abstract: The distribution of retinal gangliosides was studied in normal and mutant rats with retinal dystrophy at 30 and 180 days of age. The loss of photoreceptor cells in the retinal dystrophic RCS rats was not associated with a significant reduction in the relative distribution of any of the major retinal gangliosides. The loss of photoreceptors, however, caused a marked increase in total retinal ganglioside concentration. These findings suggest that photoreceptor cells contain a low concentration of gangliosides and that no major retinal ganglioside is localized or concentrated in these cells. The cellular localization and function of the most abundant retinal ganglioside, GD3, is discussed.

Original languageEnglish (US)
Pages (from-to)277-279
Number of pages3
JournalJournal of Neurochemistry
Volume39
Issue number1
DOIs
Publication statusPublished - Jul 1982
Externally publishedYes

Keywords

  • G
  • Gangliosides
  • Rat
  • Retina

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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