Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation

Jie Pan, Calvin D. Roskelley, Mumtaz V Rojiani, Nelly Auersperg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In embryogenesis, ovarian surface epithelial cells and ovarian granulosa cells arise through divergent differentiation from a common mesenchymal precursor, the urogenital ridge. In the adult rat, ovarian surface epithelial cells are nonsteroidogenic and keratin positive, while ovarian granulosa cells are steroidogenic and keratin negative. In culture, Kirsten murine sarcoma virus-transformed, tumorigenic ovarian surface epithelial cells continued to express keratin but also became steroidogenic. Transformed ovarian granulosa cells remained steroidogenic but also acquired keratins. Mesodermally derived cells from other sources did not show these differentiation-related changes in response to transformation. The results suggest that v-ras oncogenes may cause the reversion of adult, developmental^ related cells to the phenotype of a common, multipotential precursor. They also demonstrate the capacity of v-r<w to either induce or reduce the same differentiated characteristic, depending on the developmental history of the target cells.

Original languageEnglish (US)
Pages (from-to)4269-4272
Number of pages4
JournalCancer Research
Volume52
Issue number15
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

ras Genes
Keratins
Granulosa Cells
Epithelial Cells
Kirsten murine sarcoma virus
Embryonic Development
History
Phenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Pan, J., Roskelley, C. D., Rojiani, M. V., & Auersperg, N. (1992). Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation. Cancer Research, 52(15), 4269-4272.

Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation. / Pan, Jie; Roskelley, Calvin D.; Rojiani, Mumtaz V; Auersperg, Nelly.

In: Cancer Research, Vol. 52, No. 15, 01.01.1992, p. 4269-4272.

Research output: Contribution to journalArticle

Pan, J, Roskelley, CD, Rojiani, MV & Auersperg, N 1992, 'Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation', Cancer Research, vol. 52, no. 15, pp. 4269-4272.
Pan, Jie ; Roskelley, Calvin D. ; Rojiani, Mumtaz V ; Auersperg, Nelly. / Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation. In: Cancer Research. 1992 ; Vol. 52, No. 15. pp. 4269-4272.
@article{28348ba011a448c081a43ae0936ab950,
title = "Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation",
abstract = "In embryogenesis, ovarian surface epithelial cells and ovarian granulosa cells arise through divergent differentiation from a common mesenchymal precursor, the urogenital ridge. In the adult rat, ovarian surface epithelial cells are nonsteroidogenic and keratin positive, while ovarian granulosa cells are steroidogenic and keratin negative. In culture, Kirsten murine sarcoma virus-transformed, tumorigenic ovarian surface epithelial cells continued to express keratin but also became steroidogenic. Transformed ovarian granulosa cells remained steroidogenic but also acquired keratins. Mesodermally derived cells from other sources did not show these differentiation-related changes in response to transformation. The results suggest that v-ras oncogenes may cause the reversion of adult, developmental^ related cells to the phenotype of a common, multipotential precursor. They also demonstrate the capacity of v-r",
author = "Jie Pan and Roskelley, {Calvin D.} and Rojiani, {Mumtaz V} and Nelly Auersperg",
year = "1992",
month = "1",
day = "1",
language = "English (US)",
volume = "52",
pages = "4269--4272",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "15",

}

TY - JOUR

T1 - Reversal of Divergent Differentiation by ras Oncogene-mediated Transformation

AU - Pan, Jie

AU - Roskelley, Calvin D.

AU - Rojiani, Mumtaz V

AU - Auersperg, Nelly

PY - 1992/1/1

Y1 - 1992/1/1

N2 - In embryogenesis, ovarian surface epithelial cells and ovarian granulosa cells arise through divergent differentiation from a common mesenchymal precursor, the urogenital ridge. In the adult rat, ovarian surface epithelial cells are nonsteroidogenic and keratin positive, while ovarian granulosa cells are steroidogenic and keratin negative. In culture, Kirsten murine sarcoma virus-transformed, tumorigenic ovarian surface epithelial cells continued to express keratin but also became steroidogenic. Transformed ovarian granulosa cells remained steroidogenic but also acquired keratins. Mesodermally derived cells from other sources did not show these differentiation-related changes in response to transformation. The results suggest that v-ras oncogenes may cause the reversion of adult, developmental^ related cells to the phenotype of a common, multipotential precursor. They also demonstrate the capacity of v-r

AB - In embryogenesis, ovarian surface epithelial cells and ovarian granulosa cells arise through divergent differentiation from a common mesenchymal precursor, the urogenital ridge. In the adult rat, ovarian surface epithelial cells are nonsteroidogenic and keratin positive, while ovarian granulosa cells are steroidogenic and keratin negative. In culture, Kirsten murine sarcoma virus-transformed, tumorigenic ovarian surface epithelial cells continued to express keratin but also became steroidogenic. Transformed ovarian granulosa cells remained steroidogenic but also acquired keratins. Mesodermally derived cells from other sources did not show these differentiation-related changes in response to transformation. The results suggest that v-ras oncogenes may cause the reversion of adult, developmental^ related cells to the phenotype of a common, multipotential precursor. They also demonstrate the capacity of v-r

UR - http://www.scopus.com/inward/record.url?scp=0026646784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026646784&partnerID=8YFLogxK

M3 - Article

C2 - 1379124

AN - SCOPUS:0026646784

VL - 52

SP - 4269

EP - 4272

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 15

ER -