Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients

Mary Tavares, J. Max Goodson, Deborah Studen-Pavlovich, John A. Yagiela, Laura A. Navalta, Siegfried Rogy, Bruce Rutherford, Sharon Gordon, Athena S. Papas, Jennifer Soncini, Judith R. Chin, Jeffrey Dean, Jodie L. Jarrett, Melissa S. Mau, Paul A. Moore, Sean G. Boynes, Anne L. Lemak, Mohammad Abdulwahab, Margaret Elliott, Jayme G. ZovkoMorton Rosenberg, Mabi Singh, Nooruddin Sadruddin Pradhan, Ted P. Raybould, Jason M. Mailhot, Roy Allan Rockman, H. Thom Akins, Jennifer Balcum Turner, John L. Pfail, David V. Vaulari, Yordanka K. Ivanova, Jacqueline Kleven, Olga Pulgar-Vidal, Jean Chan, Donna L. Minnick, Gloria Martinez, Anthony Henegar

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background. The authors evaluated the safety and efficacy of a formulation of phentolamine mesylate (PM) as a local anesthesia reversal agent for pediatric patients. Methods. A total of 152 pediatric subjects received injections of local anesthetic with 2 percent lidocaine and 1:100,000 epinephrine before undergoing dental procedures. The authors then randomized subjects to receive a PM injection or a control injection (sham injection in which a needle does not penetrate the tissue) in the same sites as the local anesthetic was administered in a 1:1 cartridge ratio after the procedure was completed. Over a two- to-four-hour period, they measured the duration of soft-tissue anesthesia and evaluated vital signs, pain and adverse events. Results. The median recovery time to normal lip sensation was 60 minutes for the subjects in the PM group versus 135 minutes for subjects in the control group. The authors noted no differences in adverse events, pain, analgesic use or vital signs, and no subjects failed to complete the study. Conclusions. PM was well-tolerated and safe in children 4 to 11 years of age, and it accelerated the reversal of soft-tissue local anesthesia after a dental procedure in children 6 to 11 years of age. Clinical Implications. PM can help dental clinicians shorten the post-treatment duration of soft-tissue anesthesia and can reduce the number of posttreatment lip and tongue injuries in children.

Original languageEnglish (US)
Pages (from-to)1095-1104
Number of pages10
JournalJournal of the American Dental Association
Volume139
Issue number8
DOIs
StatePublished - Jan 1 2008

Fingerprint

Phentolamine
Local Anesthesia
Pediatrics
Tooth
Injections
Vital Signs
Lip
Local Anesthetics
Anesthesia
Pain
Proxy
Lidocaine
Tongue
Epinephrine
Needles
Analgesics
Safety
Control Groups
Wounds and Injuries

Keywords

  • Dental care for children
  • Drugs
  • Injections
  • Local anesthetics
  • Pain measurement
  • Pediatric dentistry
  • Randomized controlled clinical trials

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Tavares, M., Goodson, J. M., Studen-Pavlovich, D., Yagiela, J. A., Navalta, L. A., Rogy, S., ... Henegar, A. (2008). Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. Journal of the American Dental Association, 139(8), 1095-1104. https://doi.org/10.14219/jada.archive.2008.0312

Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. / Tavares, Mary; Goodson, J. Max; Studen-Pavlovich, Deborah; Yagiela, John A.; Navalta, Laura A.; Rogy, Siegfried; Rutherford, Bruce; Gordon, Sharon; Papas, Athena S.; Soncini, Jennifer; Chin, Judith R.; Dean, Jeffrey; Jarrett, Jodie L.; Mau, Melissa S.; Moore, Paul A.; Boynes, Sean G.; Lemak, Anne L.; Abdulwahab, Mohammad; Elliott, Margaret; Zovko, Jayme G.; Rosenberg, Morton; Singh, Mabi; Pradhan, Nooruddin Sadruddin; Raybould, Ted P.; Mailhot, Jason M.; Rockman, Roy Allan; Akins, H. Thom; Turner, Jennifer Balcum; Pfail, John L.; Vaulari, David V.; Ivanova, Yordanka K.; Kleven, Jacqueline; Pulgar-Vidal, Olga; Chan, Jean; Minnick, Donna L.; Martinez, Gloria; Henegar, Anthony.

In: Journal of the American Dental Association, Vol. 139, No. 8, 01.01.2008, p. 1095-1104.

Research output: Contribution to journalArticle

Tavares, M, Goodson, JM, Studen-Pavlovich, D, Yagiela, JA, Navalta, LA, Rogy, S, Rutherford, B, Gordon, S, Papas, AS, Soncini, J, Chin, JR, Dean, J, Jarrett, JL, Mau, MS, Moore, PA, Boynes, SG, Lemak, AL, Abdulwahab, M, Elliott, M, Zovko, JG, Rosenberg, M, Singh, M, Pradhan, NS, Raybould, TP, Mailhot, JM, Rockman, RA, Akins, HT, Turner, JB, Pfail, JL, Vaulari, DV, Ivanova, YK, Kleven, J, Pulgar-Vidal, O, Chan, J, Minnick, DL, Martinez, G & Henegar, A 2008, 'Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients', Journal of the American Dental Association, vol. 139, no. 8, pp. 1095-1104. https://doi.org/10.14219/jada.archive.2008.0312
Tavares, Mary ; Goodson, J. Max ; Studen-Pavlovich, Deborah ; Yagiela, John A. ; Navalta, Laura A. ; Rogy, Siegfried ; Rutherford, Bruce ; Gordon, Sharon ; Papas, Athena S. ; Soncini, Jennifer ; Chin, Judith R. ; Dean, Jeffrey ; Jarrett, Jodie L. ; Mau, Melissa S. ; Moore, Paul A. ; Boynes, Sean G. ; Lemak, Anne L. ; Abdulwahab, Mohammad ; Elliott, Margaret ; Zovko, Jayme G. ; Rosenberg, Morton ; Singh, Mabi ; Pradhan, Nooruddin Sadruddin ; Raybould, Ted P. ; Mailhot, Jason M. ; Rockman, Roy Allan ; Akins, H. Thom ; Turner, Jennifer Balcum ; Pfail, John L. ; Vaulari, David V. ; Ivanova, Yordanka K. ; Kleven, Jacqueline ; Pulgar-Vidal, Olga ; Chan, Jean ; Minnick, Donna L. ; Martinez, Gloria ; Henegar, Anthony. / Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. In: Journal of the American Dental Association. 2008 ; Vol. 139, No. 8. pp. 1095-1104.
@article{1b859e01d0b84e4793588140a0e98682,
title = "Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients",
abstract = "Background. The authors evaluated the safety and efficacy of a formulation of phentolamine mesylate (PM) as a local anesthesia reversal agent for pediatric patients. Methods. A total of 152 pediatric subjects received injections of local anesthetic with 2 percent lidocaine and 1:100,000 epinephrine before undergoing dental procedures. The authors then randomized subjects to receive a PM injection or a control injection (sham injection in which a needle does not penetrate the tissue) in the same sites as the local anesthetic was administered in a 1:1 cartridge ratio after the procedure was completed. Over a two- to-four-hour period, they measured the duration of soft-tissue anesthesia and evaluated vital signs, pain and adverse events. Results. The median recovery time to normal lip sensation was 60 minutes for the subjects in the PM group versus 135 minutes for subjects in the control group. The authors noted no differences in adverse events, pain, analgesic use or vital signs, and no subjects failed to complete the study. Conclusions. PM was well-tolerated and safe in children 4 to 11 years of age, and it accelerated the reversal of soft-tissue local anesthesia after a dental procedure in children 6 to 11 years of age. Clinical Implications. PM can help dental clinicians shorten the post-treatment duration of soft-tissue anesthesia and can reduce the number of posttreatment lip and tongue injuries in children.",
keywords = "Dental care for children, Drugs, Injections, Local anesthetics, Pain measurement, Pediatric dentistry, Randomized controlled clinical trials",
author = "Mary Tavares and Goodson, {J. Max} and Deborah Studen-Pavlovich and Yagiela, {John A.} and Navalta, {Laura A.} and Siegfried Rogy and Bruce Rutherford and Sharon Gordon and Papas, {Athena S.} and Jennifer Soncini and Chin, {Judith R.} and Jeffrey Dean and Jarrett, {Jodie L.} and Mau, {Melissa S.} and Moore, {Paul A.} and Boynes, {Sean G.} and Lemak, {Anne L.} and Mohammad Abdulwahab and Margaret Elliott and Zovko, {Jayme G.} and Morton Rosenberg and Mabi Singh and Pradhan, {Nooruddin Sadruddin} and Raybould, {Ted P.} and Mailhot, {Jason M.} and Rockman, {Roy Allan} and Akins, {H. Thom} and Turner, {Jennifer Balcum} and Pfail, {John L.} and Vaulari, {David V.} and Ivanova, {Yordanka K.} and Jacqueline Kleven and Olga Pulgar-Vidal and Jean Chan and Minnick, {Donna L.} and Gloria Martinez and Anthony Henegar",
year = "2008",
month = "1",
day = "1",
doi = "10.14219/jada.archive.2008.0312",
language = "English (US)",
volume = "139",
pages = "1095--1104",
journal = "Journal of the American Dental Association",
issn = "0002-8177",
publisher = "American Dental Association",
number = "8",

}

TY - JOUR

T1 - Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients

AU - Tavares, Mary

AU - Goodson, J. Max

AU - Studen-Pavlovich, Deborah

AU - Yagiela, John A.

AU - Navalta, Laura A.

AU - Rogy, Siegfried

AU - Rutherford, Bruce

AU - Gordon, Sharon

AU - Papas, Athena S.

AU - Soncini, Jennifer

AU - Chin, Judith R.

AU - Dean, Jeffrey

AU - Jarrett, Jodie L.

AU - Mau, Melissa S.

AU - Moore, Paul A.

AU - Boynes, Sean G.

AU - Lemak, Anne L.

AU - Abdulwahab, Mohammad

AU - Elliott, Margaret

AU - Zovko, Jayme G.

AU - Rosenberg, Morton

AU - Singh, Mabi

AU - Pradhan, Nooruddin Sadruddin

AU - Raybould, Ted P.

AU - Mailhot, Jason M.

AU - Rockman, Roy Allan

AU - Akins, H. Thom

AU - Turner, Jennifer Balcum

AU - Pfail, John L.

AU - Vaulari, David V.

AU - Ivanova, Yordanka K.

AU - Kleven, Jacqueline

AU - Pulgar-Vidal, Olga

AU - Chan, Jean

AU - Minnick, Donna L.

AU - Martinez, Gloria

AU - Henegar, Anthony

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background. The authors evaluated the safety and efficacy of a formulation of phentolamine mesylate (PM) as a local anesthesia reversal agent for pediatric patients. Methods. A total of 152 pediatric subjects received injections of local anesthetic with 2 percent lidocaine and 1:100,000 epinephrine before undergoing dental procedures. The authors then randomized subjects to receive a PM injection or a control injection (sham injection in which a needle does not penetrate the tissue) in the same sites as the local anesthetic was administered in a 1:1 cartridge ratio after the procedure was completed. Over a two- to-four-hour period, they measured the duration of soft-tissue anesthesia and evaluated vital signs, pain and adverse events. Results. The median recovery time to normal lip sensation was 60 minutes for the subjects in the PM group versus 135 minutes for subjects in the control group. The authors noted no differences in adverse events, pain, analgesic use or vital signs, and no subjects failed to complete the study. Conclusions. PM was well-tolerated and safe in children 4 to 11 years of age, and it accelerated the reversal of soft-tissue local anesthesia after a dental procedure in children 6 to 11 years of age. Clinical Implications. PM can help dental clinicians shorten the post-treatment duration of soft-tissue anesthesia and can reduce the number of posttreatment lip and tongue injuries in children.

AB - Background. The authors evaluated the safety and efficacy of a formulation of phentolamine mesylate (PM) as a local anesthesia reversal agent for pediatric patients. Methods. A total of 152 pediatric subjects received injections of local anesthetic with 2 percent lidocaine and 1:100,000 epinephrine before undergoing dental procedures. The authors then randomized subjects to receive a PM injection or a control injection (sham injection in which a needle does not penetrate the tissue) in the same sites as the local anesthetic was administered in a 1:1 cartridge ratio after the procedure was completed. Over a two- to-four-hour period, they measured the duration of soft-tissue anesthesia and evaluated vital signs, pain and adverse events. Results. The median recovery time to normal lip sensation was 60 minutes for the subjects in the PM group versus 135 minutes for subjects in the control group. The authors noted no differences in adverse events, pain, analgesic use or vital signs, and no subjects failed to complete the study. Conclusions. PM was well-tolerated and safe in children 4 to 11 years of age, and it accelerated the reversal of soft-tissue local anesthesia after a dental procedure in children 6 to 11 years of age. Clinical Implications. PM can help dental clinicians shorten the post-treatment duration of soft-tissue anesthesia and can reduce the number of posttreatment lip and tongue injuries in children.

KW - Dental care for children

KW - Drugs

KW - Injections

KW - Local anesthetics

KW - Pain measurement

KW - Pediatric dentistry

KW - Randomized controlled clinical trials

UR - http://www.scopus.com/inward/record.url?scp=52449128975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52449128975&partnerID=8YFLogxK

U2 - 10.14219/jada.archive.2008.0312

DO - 10.14219/jada.archive.2008.0312

M3 - Article

C2 - 18682624

AN - SCOPUS:52449128975

VL - 139

SP - 1095

EP - 1104

JO - Journal of the American Dental Association

JF - Journal of the American Dental Association

SN - 0002-8177

IS - 8

ER -