RhoA/Rho-kinase

A novel player in the regulation of penile erection

K. Chitaley, R Clinton Webb, T. M. Mills

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Current research has centered around the role of nitric oxide in the stimulation of cavernosal vasodilation and erection. However, recent evidence from our lab details the importance of endogenous vasoconstrictor mechanisms in maintaining a flaccid penile state, and further demonstrates that the inhibition of endogenous vasoconstriction is sufficient to stimulate erection in a rat model. In this article, we suggest inhibition of endogenous vasoconstriction as a potential therapeutic avenue in the treatment of erectile dysfunction. We also speculate on potential physiologic mechanisms by which endogenous vasoconstriction is inhibited in order for arousal-initiated vasorelaxation, and erection, to occur.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalInternational Journal of Impotence Research
Volume13
Issue number2
DOIs
StatePublished - Jun 15 2001

Fingerprint

Penile Erection
rho-Associated Kinases
Vasoconstriction
Vasodilation
Vasoconstrictor Agents
Erectile Dysfunction
Arousal
Nitric Oxide
Therapeutics
Research
Inhibition (Psychology)

Keywords

  • Erectile dysfunction
  • Nitric oxide
  • Rho-kinase

ASJC Scopus subject areas

  • Urology

Cite this

RhoA/Rho-kinase : A novel player in the regulation of penile erection. / Chitaley, K.; Webb, R Clinton; Mills, T. M.

In: International Journal of Impotence Research, Vol. 13, No. 2, 15.06.2001, p. 67-72.

Research output: Contribution to journalArticle

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