RhoA/Rho-kinase: A novel player in the regulation of penile erection

K. Chitaley, R. C. Webb, T. M. Mills

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Current research has centered around the role of nitric oxide in the stimulation of cavernosal vasodilation and erection. However, recent evidence from our lab details the importance of endogenous vasoconstrictor mechanisms in maintaining a flaccid penile state, and further demonstrates that the inhibition of endogenous vasoconstriction is sufficient to stimulate erection in a rat model. In this article, we suggest inhibition of endogenous vasoconstriction as a potential therapeutic avenue in the treatment of erectile dysfunction. We also speculate on potential physiologic mechanisms by which endogenous vasoconstriction is inhibited in order for arousal-initiated vasorelaxation, and erection, to occur.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalInternational journal of impotence research
Volume13
Issue number2
DOIs
StatePublished - Jun 15 2001

Keywords

  • Erectile dysfunction
  • Nitric oxide
  • Rho-kinase

ASJC Scopus subject areas

  • Urology

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