Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome

Yunhui Wang, Xiaomiao Zhao, Huidan Zhao, Hong Ding, Jianping Tan, Jingte Chen, Rui Zhang, Ricardo Azziz, Dongzi Yang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.

Original languageEnglish (US)
Article number182582
JournalBioMed Research International
Volume2013
DOIs
StatePublished - Dec 1 2013

Fingerprint

Pregnancy Induced Hypertension
Gestational Diabetes
Polycystic Ovary Syndrome
Medical problems
Ovulation Induction
Twinning
Incidence
Glucose
High-Risk Pregnancy
Premature Birth
Pregnancy Outcome
Fetal Development
Pregnancy
Control Groups

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome. / Wang, Yunhui; Zhao, Xiaomiao; Zhao, Huidan; Ding, Hong; Tan, Jianping; Chen, Jingte; Zhang, Rui; Azziz, Ricardo; Yang, Dongzi.

In: BioMed Research International, Vol. 2013, 182582, 01.12.2013.

Research output: Contribution to journalArticle

Wang, Yunhui ; Zhao, Xiaomiao ; Zhao, Huidan ; Ding, Hong ; Tan, Jianping ; Chen, Jingte ; Zhang, Rui ; Azziz, Ricardo ; Yang, Dongzi. / Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome. In: BioMed Research International. 2013 ; Vol. 2013.
@article{5e37bea1bd1c41088970d3ef877a2d55,
title = "Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome",
abstract = "Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9{\%}; OR: 2.9, 95{\%} CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5{\%}; OR: 3.3, 95{\%} CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3{\%}; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4{\%}; OR: 2.2, 95{\%} CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8{\%}; OR: 2.6, 95{\%} CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1{\%}) or ovarian stimulation (9.4{\%}). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1{\%} versus 14.5{\%}; OR: 5.6, 95{\%} CI: 3.4-9.0) and PIH (8.9{\%} versus 3.2{\%}; OR: 3.0, 95{\%} CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95{\%} CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.",
author = "Yunhui Wang and Xiaomiao Zhao and Huidan Zhao and Hong Ding and Jianping Tan and Jingte Chen and Rui Zhang and Ricardo Azziz and Dongzi Yang",
year = "2013",
month = "12",
day = "1",
doi = "10.1155/2013/182582",
language = "English (US)",
volume = "2013",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Risks for gestational diabetes mellitus and pregnancy-induced hypertension are increased in polycystic ovary syndrome

AU - Wang, Yunhui

AU - Zhao, Xiaomiao

AU - Zhao, Huidan

AU - Ding, Hong

AU - Tan, Jianping

AU - Chen, Jingte

AU - Zhang, Rui

AU - Azziz, Ricardo

AU - Yang, Dongzi

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.

AB - Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0-4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0-5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%; P < 0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1-4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1-6.2; P < 0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI < 24 kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4-9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3-7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3-11.7). Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered with ChiCTR-RCC-11001824.

UR - http://www.scopus.com/inward/record.url?scp=84893812979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893812979&partnerID=8YFLogxK

U2 - 10.1155/2013/182582

DO - 10.1155/2013/182582

M3 - Article

VL - 2013

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 182582

ER -