Role of adrenal steroids on electroacupuncture analgesia and on antagonising potency of naloxone

Sumantra Das, Tapan Kumar Chatterjee, A. Ganguly, J. J. Ghosh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electroacupuncture (EA), a form of transcutaneous electrical stimulation, produces opiate-like antinociception and catalepsy in rats. This effect of EA cannot be produced in hypophysectomised rats, whereas adrenalectomised rats show increased sensitivity. In intact rats, adrenocorticotrophic hormone and dexamethasone have been found to be effective to sensitise the animals to the analgesic effect of EA. Deoxycorticosterone, on the contrary, attenuates this effect. Spironolactone is also effective to potentiate EA response, which is accompanied with severe respiratory depression. Drugs that are known to affect adrenal aldosterone secretion also modulate the effect of EA. Naloxone administration, 15 min prior to the initiation of EA stimulation, potentiates the effect of EA, whereas it counteracts the effect of EA if administered after initiation of EA stimulation. Moreover, this counteracting ability of naloxone increases with the increase in time interval between initiation of stimulation and naloxone challenge. Pretreatment with drugs that impair adrenal mineralocorticoid response to physiological stimuli inhibits the counteracting effect of naloxone. On the contrary, mineralocorticoid supplemented rats show greater sensitivity to naloxone counteraction.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalPain
Volume18
Issue number2
DOIs
StatePublished - Jan 1 1984

Fingerprint

Electroacupuncture
Naloxone
Analgesia
Steroids
Mineralocorticoids
Opiate Alkaloids
Catalepsy
Transcutaneous Electric Nerve Stimulation
Desoxycorticosterone
Spironolactone
Aldosterone
Respiratory Insufficiency
Pharmaceutical Preparations
Adrenocorticotropic Hormone
Dexamethasone
Analgesics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Role of adrenal steroids on electroacupuncture analgesia and on antagonising potency of naloxone. / Das, Sumantra; Chatterjee, Tapan Kumar; Ganguly, A.; Ghosh, J. J.

In: Pain, Vol. 18, No. 2, 01.01.1984, p. 135-143.

Research output: Contribution to journalArticle

Das, Sumantra ; Chatterjee, Tapan Kumar ; Ganguly, A. ; Ghosh, J. J. / Role of adrenal steroids on electroacupuncture analgesia and on antagonising potency of naloxone. In: Pain. 1984 ; Vol. 18, No. 2. pp. 135-143.
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