Role of immune cells in salt-sensitive hypertension and renal injury

Research output: Contribution to journalReview article

Abstract

Purpose of review Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease. Recent findings Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens. Summary Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Renal Hypertension
Salts
Hypertension
T-Lymphocytes
Animal Disease Models
Wounds and Injuries
Adaptive Immunity
Immunity
Antigens
Therapeutics

Keywords

  • Immunity
  • lymphocytes
  • renal disease
  • sodium-dependent hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

Cite this

Role of immune cells in salt-sensitive hypertension and renal injury. / Wade, Brittany; Abais-Battad, Justine M.; Mattson, David L.

In: Current opinion in nephrology and hypertension, Vol. 25, No. 1, 01.01.2016, p. 22-27.

Research output: Contribution to journalReview article

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