Abstract
T lymphocytes mature in the thymus where they encounter peptides derived from self proteins of the body presented by MHC class I and class II molecules. Recognition of both peptides and MHC leads to negative and positive selection of T cells bearing appropriate antigen receptors. The role of self-peptides bound to MHC molecules in negative selection is well established. Such a role in positive selection has only recently been scrutinized and many issues are still controversial. These topics are discussed in this review. A new transgenic mouse has been recently generated that displays only one peptide covalently bound to all class II MHC molecules in the body. The process of positive selection in that mouse is presented here in more detail.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-182 |
| Number of pages | 14 |
| Journal | Central-European Journal of Immunology |
| Volume | 23 |
| Issue number | 3-4 |
| State | Published - Jan 1 1998 |
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Keywords
- MHC
- Positive selection
- T lymphocytes
- Thymus
- Transgenic mouse
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Role of peptide ligand in the positive selection of T lymphocytes. / Kusnierczyk, P.; Pacholczyk, R.; Chmielowski, B.; Ignatowicz, L.
In: Central-European Journal of Immunology, Vol. 23, No. 3-4, 01.01.1998, p. 169-182.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Role of peptide ligand in the positive selection of T lymphocytes
AU - Kusnierczyk, P.
AU - Pacholczyk, R.
AU - Chmielowski, B.
AU - Ignatowicz, L.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - T lymphocytes mature in the thymus where they encounter peptides derived from self proteins of the body presented by MHC class I and class II molecules. Recognition of both peptides and MHC leads to negative and positive selection of T cells bearing appropriate antigen receptors. The role of self-peptides bound to MHC molecules in negative selection is well established. Such a role in positive selection has only recently been scrutinized and many issues are still controversial. These topics are discussed in this review. A new transgenic mouse has been recently generated that displays only one peptide covalently bound to all class II MHC molecules in the body. The process of positive selection in that mouse is presented here in more detail.
AB - T lymphocytes mature in the thymus where they encounter peptides derived from self proteins of the body presented by MHC class I and class II molecules. Recognition of both peptides and MHC leads to negative and positive selection of T cells bearing appropriate antigen receptors. The role of self-peptides bound to MHC molecules in negative selection is well established. Such a role in positive selection has only recently been scrutinized and many issues are still controversial. These topics are discussed in this review. A new transgenic mouse has been recently generated that displays only one peptide covalently bound to all class II MHC molecules in the body. The process of positive selection in that mouse is presented here in more detail.
KW - MHC
KW - Positive selection
KW - T lymphocytes
KW - Thymus
KW - Transgenic mouse
UR - http://www.scopus.com/inward/record.url?scp=0032468240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032468240&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:0032468240
VL - 23
SP - 169
EP - 182
JO - Central-European Journal of Immunology
JF - Central-European Journal of Immunology
SN - 1426-3912
IS - 3-4
ER -