Role of peptide ligand in the positive selection of T lymphocytes

P. Kusnierczyk, R. Pacholczyk, B. Chmielowski, L. Ignatowicz

Research output: Contribution to journalReview article

Abstract

T lymphocytes mature in the thymus where they encounter peptides derived from self proteins of the body presented by MHC class I and class II molecules. Recognition of both peptides and MHC leads to negative and positive selection of T cells bearing appropriate antigen receptors. The role of self-peptides bound to MHC molecules in negative selection is well established. Such a role in positive selection has only recently been scrutinized and many issues are still controversial. These topics are discussed in this review. A new transgenic mouse has been recently generated that displays only one peptide covalently bound to all class II MHC molecules in the body. The process of positive selection in that mouse is presented here in more detail.

Original languageEnglish (US)
Pages (from-to)169-182
Number of pages14
JournalCentral-European Journal of Immunology
Volume23
Issue number3-4
StatePublished - Jan 1 1998

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Keywords

  • MHC
  • Positive selection
  • T lymphocytes
  • Thymus
  • Transgenic mouse

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kusnierczyk, P., Pacholczyk, R., Chmielowski, B., & Ignatowicz, L. (1998). Role of peptide ligand in the positive selection of T lymphocytes. Central-European Journal of Immunology, 23(3-4), 169-182.