The thrombin-induced dysfunction of the barrier function of the blood vessel endothelium, which manifests itself in increased permeability, is largely mediated via the initiation of specific receptors that trigger multiple signaling cascades, including the activation of some protein kinases and the phosphorylation of their cytoskeletal targets. The role of the phosphorylation of myosin and actin-binding proteins in the thrombin-induced permeability of the endothelium and possible mechanisms of the regulation of the endothelium barrier function are discussed.
|Original language||English (US)|
|Number of pages||7|
|Journal||Russian Journal of Bioorganic Chemistry|
|State||Published - Sep 2003|
- Endothelial cell barrier function
ASJC Scopus subject areas
- Organic Chemistry