Role of Phosphorylation of Myosin- and Actin-Binding Proteins in Thrombin-Induced Permeability of Endothelial Cells

T. Borbiev, J. G.N. Garcia, A. D. Verin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The thrombin-induced dysfunction of the barrier function of the blood vessel endothelium, which manifests itself in increased permeability, is largely mediated via the initiation of specific receptors that trigger multiple signaling cascades, including the activation of some protein kinases and the phosphorylation of their cytoskeletal targets. The role of the phosphorylation of myosin and actin-binding proteins in the thrombin-induced permeability of the endothelium and possible mechanisms of the regulation of the endothelium barrier function are discussed.

Original languageEnglish (US)
Pages (from-to)464-470
Number of pages7
JournalRussian Journal of Bioorganic Chemistry
Volume29
Issue number5
DOIs
Publication statusPublished - Sep 1 2003
Externally publishedYes

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Keywords

  • Cytoskeleton
  • Endothelial cell barrier function
  • Thrombin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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