Role of Rab GTPases in the export trafficking of G protein-coupled receptors

Guansong Wang, Zhe Wei, Guangyu Wu

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. As the cell surface is the functional destination for most GPCRs, the cell surface targeting process represents a crucial checkpoint in controlling the functionality of the receptors. However, the molecular mechanisms underlying the cell surface delivery of newly synthesized GPCRs remain poorly understood. In this review, we will highlight the role of Rab GTPases in GPCR cell surface transport, particularly post-Golgi traffic, and discuss the underlying molecular mechanisms.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalSmall GTPases
Volume9
Issue number1-2
DOIs
StatePublished - Mar 4 2018

Keywords

  • G protein-coupled receptor
  • Rab GTPase
  • Rab26
  • Rab8
  • cell surface expression
  • export trafficking
  • post-Golgi traffic

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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