STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.
|Original language||English (US)|
|Title of host publication||Role of Transcription Factors in Gastrointestinal Malignancies|
|Number of pages||10|
|State||Published - Jan 1 2018|
- Pancreatic cancer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)