Role of STAT3 in Pancreatic Cancer: A target for therapy

Waaqo B. Daddacha, Allyson E. Koyen, Ashley J. Schlafstein, David S. Yu

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Original languageEnglish (US)
Title of host publicationRole of Transcription Factors in Gastrointestinal Malignancies
PublisherSpringer Singapore
Pages339-348
Number of pages10
ISBN (Electronic)9789811067280
ISBN (Print)9789811067273
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Immunotherapy
  • Pancreatic cancer
  • STAT3

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Daddacha, W. B., Koyen, A. E., Schlafstein, A. J., & Yu, D. S. (2018). Role of STAT3 in Pancreatic Cancer: A target for therapy. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 339-348). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_24