Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations

Sherman M Chamberlain, J. Carter Balart, Kostas Sideridis, Jefrey Salek, Subbaramiah Sridhar, William O. Thompson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to investigate whether an oral sodium phosphate solution (OSPS) mixed with aspartame-based clear liquids as the diluent would yield improved colon cleansing results compared to an OSPS mixed with sucrose-based liquids as the diluent. Fifty-one patients undergoing colonoscopy were prospectively randomized into two groups to receive different OSPS colonoscopy preparations, with sucrose-based or aspartame-based liquids used as diluents. The primary end point was the quality of the colonoscopy preparation and secondary end points were serum electrolytes before and after preparations. No significant difference in colonoscopy preparation quality was seen between the two OSPS diluent groups (Mantel-Haenzel χ 2 = 0.795, P = 0.484). There were no significant differences in mean electrolyte shifts of sodium, potassium, blood urea nitrogen (BUN), creatinine (Cr), or BUN/Cr ratios between the two groups. There was a statistically significant increase in serum phosphorous in the aspartame-based group compared to the sucrose-based diluent group (P = 0.021). In conclusion, there was no clinically detectable difference in colonoscopy preparation quality between the two OSPS diluent groups. This study suggests that passive fluid transport by aquaporins may well be the major mediator of fluid shifts in the study subjects. This result suggests the potential importance of aquaporins and minimizes the importance of sodium glucose cotransporter SGLT1 in fluid and electrolyte transport in the human gastrointestinal tract. Aspartame or its constituent amino acids may enhance phosphate absorption across the human small intestine.

Original languageEnglish (US)
Pages (from-to)3165-3168
Number of pages4
JournalDigestive Diseases and Sciences
Volume52
Issue number11
DOIs
StatePublished - Nov 1 2007

Fingerprint

Aspartame
Colonoscopy
Sucrose
Safety
Electrolytes
Aquaporins
Blood Urea Nitrogen
Creatinine
Sodium-Glucose Transport Proteins
Fluid Shifts
Serum
Small Intestine
Gastrointestinal Tract
Potassium
Colon
Sodium
Phosphates
sodium phosphate
Amino Acids

Keywords

  • Aquaporins
  • Colonoscopy preparation
  • Colonoscopy preparation quality
  • Fleet Phosph-soda
  • Gastrointestinal tract fluid transport
  • Oral sodium phosphate solution
  • Phosphate absorption
  • Sodium glucose coupled transporter

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations. / Chamberlain, Sherman M; Balart, J. Carter; Sideridis, Kostas; Salek, Jefrey; Sridhar, Subbaramiah; Thompson, William O.

In: Digestive Diseases and Sciences, Vol. 52, No. 11, 01.11.2007, p. 3165-3168.

Research output: Contribution to journalArticle

Chamberlain, Sherman M ; Balart, J. Carter ; Sideridis, Kostas ; Salek, Jefrey ; Sridhar, Subbaramiah ; Thompson, William O. / Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations. In: Digestive Diseases and Sciences. 2007 ; Vol. 52, No. 11. pp. 3165-3168.
@article{9b9d411a9a16440391595601a9c4354b,
title = "Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations",
abstract = "The aim of this study was to investigate whether an oral sodium phosphate solution (OSPS) mixed with aspartame-based clear liquids as the diluent would yield improved colon cleansing results compared to an OSPS mixed with sucrose-based liquids as the diluent. Fifty-one patients undergoing colonoscopy were prospectively randomized into two groups to receive different OSPS colonoscopy preparations, with sucrose-based or aspartame-based liquids used as diluents. The primary end point was the quality of the colonoscopy preparation and secondary end points were serum electrolytes before and after preparations. No significant difference in colonoscopy preparation quality was seen between the two OSPS diluent groups (Mantel-Haenzel χ 2 = 0.795, P = 0.484). There were no significant differences in mean electrolyte shifts of sodium, potassium, blood urea nitrogen (BUN), creatinine (Cr), or BUN/Cr ratios between the two groups. There was a statistically significant increase in serum phosphorous in the aspartame-based group compared to the sucrose-based diluent group (P = 0.021). In conclusion, there was no clinically detectable difference in colonoscopy preparation quality between the two OSPS diluent groups. This study suggests that passive fluid transport by aquaporins may well be the major mediator of fluid shifts in the study subjects. This result suggests the potential importance of aquaporins and minimizes the importance of sodium glucose cotransporter SGLT1 in fluid and electrolyte transport in the human gastrointestinal tract. Aspartame or its constituent amino acids may enhance phosphate absorption across the human small intestine.",
keywords = "Aquaporins, Colonoscopy preparation, Colonoscopy preparation quality, Fleet Phosph-soda, Gastrointestinal tract fluid transport, Oral sodium phosphate solution, Phosphate absorption, Sodium glucose coupled transporter",
author = "Chamberlain, {Sherman M} and Balart, {J. Carter} and Kostas Sideridis and Jefrey Salek and Subbaramiah Sridhar and Thompson, {William O.}",
year = "2007",
month = "11",
day = "1",
doi = "10.1007/s10620-007-9790-8",
language = "English (US)",
volume = "52",
pages = "3165--3168",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "11",

}

TY - JOUR

T1 - Safety and efficacy of aspartame-based liquid versus sucrose-based liquids used for dilution in oral sodium phosphate solutions for colonoscopy preparations

AU - Chamberlain, Sherman M

AU - Balart, J. Carter

AU - Sideridis, Kostas

AU - Salek, Jefrey

AU - Sridhar, Subbaramiah

AU - Thompson, William O.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - The aim of this study was to investigate whether an oral sodium phosphate solution (OSPS) mixed with aspartame-based clear liquids as the diluent would yield improved colon cleansing results compared to an OSPS mixed with sucrose-based liquids as the diluent. Fifty-one patients undergoing colonoscopy were prospectively randomized into two groups to receive different OSPS colonoscopy preparations, with sucrose-based or aspartame-based liquids used as diluents. The primary end point was the quality of the colonoscopy preparation and secondary end points were serum electrolytes before and after preparations. No significant difference in colonoscopy preparation quality was seen between the two OSPS diluent groups (Mantel-Haenzel χ 2 = 0.795, P = 0.484). There were no significant differences in mean electrolyte shifts of sodium, potassium, blood urea nitrogen (BUN), creatinine (Cr), or BUN/Cr ratios between the two groups. There was a statistically significant increase in serum phosphorous in the aspartame-based group compared to the sucrose-based diluent group (P = 0.021). In conclusion, there was no clinically detectable difference in colonoscopy preparation quality between the two OSPS diluent groups. This study suggests that passive fluid transport by aquaporins may well be the major mediator of fluid shifts in the study subjects. This result suggests the potential importance of aquaporins and minimizes the importance of sodium glucose cotransporter SGLT1 in fluid and electrolyte transport in the human gastrointestinal tract. Aspartame or its constituent amino acids may enhance phosphate absorption across the human small intestine.

AB - The aim of this study was to investigate whether an oral sodium phosphate solution (OSPS) mixed with aspartame-based clear liquids as the diluent would yield improved colon cleansing results compared to an OSPS mixed with sucrose-based liquids as the diluent. Fifty-one patients undergoing colonoscopy were prospectively randomized into two groups to receive different OSPS colonoscopy preparations, with sucrose-based or aspartame-based liquids used as diluents. The primary end point was the quality of the colonoscopy preparation and secondary end points were serum electrolytes before and after preparations. No significant difference in colonoscopy preparation quality was seen between the two OSPS diluent groups (Mantel-Haenzel χ 2 = 0.795, P = 0.484). There were no significant differences in mean electrolyte shifts of sodium, potassium, blood urea nitrogen (BUN), creatinine (Cr), or BUN/Cr ratios between the two groups. There was a statistically significant increase in serum phosphorous in the aspartame-based group compared to the sucrose-based diluent group (P = 0.021). In conclusion, there was no clinically detectable difference in colonoscopy preparation quality between the two OSPS diluent groups. This study suggests that passive fluid transport by aquaporins may well be the major mediator of fluid shifts in the study subjects. This result suggests the potential importance of aquaporins and minimizes the importance of sodium glucose cotransporter SGLT1 in fluid and electrolyte transport in the human gastrointestinal tract. Aspartame or its constituent amino acids may enhance phosphate absorption across the human small intestine.

KW - Aquaporins

KW - Colonoscopy preparation

KW - Colonoscopy preparation quality

KW - Fleet Phosph-soda

KW - Gastrointestinal tract fluid transport

KW - Oral sodium phosphate solution

KW - Phosphate absorption

KW - Sodium glucose coupled transporter

UR - http://www.scopus.com/inward/record.url?scp=34848906565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848906565&partnerID=8YFLogxK

U2 - 10.1007/s10620-007-9790-8

DO - 10.1007/s10620-007-9790-8

M3 - Article

C2 - 17406813

AN - SCOPUS:34848906565

VL - 52

SP - 3165

EP - 3168

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 11

ER -