Selected biological activities of novel selenonium choline analogs

A. V. Terry, Louis A. Silks, R. B. Dunlap, J. D. Odom, J. W. Kosh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. 1. The novel choline analogs selenonium choline (SeCh) and acetylselenonium choline (ASeCh) have been examined for selected biological activities. 2. 2. ASeCh was found to be an alternative substrate for acetylcholin esterase with Km and Vmax values similar to acetylcholine. 3. 3. ASeCh and SeCh inhibited acetylthiocholine hydrolysis by acetylcholinesterase with IC50 values similar to acetylcholine and choline. 4. 4. SeCh exerted a protective action against physostigmine and DFP induced toxicity. 5. 5. SeCh (85 mg/kg) was found to be 3 times more toxic in mice than choline.

Original languageEnglish (US)
Pages (from-to)689-692
Number of pages4
JournalGeneral Pharmacology
Volume23
Issue number4
DOIs
StatePublished - Jul 1992

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Choline
Acetylcholine
Acetylthiocholine
Isoflurophate
Physostigmine
Poisons
Esterases
Acetylcholinesterase
Inhibitory Concentration 50
Hydrolysis
selenonium choline
acetylselenonium choline

ASJC Scopus subject areas

  • Pharmacology

Cite this

Selected biological activities of novel selenonium choline analogs. / Terry, A. V.; Silks, Louis A.; Dunlap, R. B.; Odom, J. D.; Kosh, J. W.

In: General Pharmacology, Vol. 23, No. 4, 07.1992, p. 689-692.

Research output: Contribution to journalArticle

Terry, A. V. ; Silks, Louis A. ; Dunlap, R. B. ; Odom, J. D. ; Kosh, J. W. / Selected biological activities of novel selenonium choline analogs. In: General Pharmacology. 1992 ; Vol. 23, No. 4. pp. 689-692.
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