Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Masoud Delfi, Rossella Sartorius, Milad Ashrafizadeh, Esmaeel Sharifi, Yapei Zhang, Piergiuseppe De Berardinis, Ali Zarrabi, Rajender S. Varma, Franklin R. Tay, Bryan Ronain Smith, Pooyan Makvandi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Self-assembled peptides and proteins possess tremendous potential as targeted drug delivery systems and key applications of these well-defined nanostructures reside in anti-cancer therapy. Peptides and proteins can self-assemble into nanostructures of diverse sizes and shapes in response to changing environmental conditions such as pH, temperature, ionic strength, as well as host and guest molecular interactions; their countless benefits include good biocompatibility and high loading capacity for hydrophobic and hydrophilic drugs. These self-assembled nanomaterials can be adorned with functional moieties to specifically target tumor cells. Stimuli-responsive features can also be incorporated with respect to the tumor microenvironment. This review sheds light on the growing interest in self-assembled peptides and proteins and their burgeoning applications in cancer treatment and immunotherapy.

Original languageEnglish (US)
Article number101119
JournalNano Today
Volume38
DOIs
StatePublished - Jun 2021

Keywords

  • Cancer therapy
  • Drug delivery
  • Immunotherapy
  • Self-assembled peptides and proteins
  • Stimuli-responsive
  • Virus-like particles

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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