Senile plaques exert no mass lesion effect on surrounding neurons

Manuel F. Casanova, William D Hill, Benam Pourdihimi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Since the turn of the century studies have suggested that clinical deterioration in Alzheimer's disease (AD) is accompanied by a gradual increase in both the size and numbers of senile plaques (SP's). Our study investigated the 'mass effect' of SP's on the morphometry of adjacent neurons. For this purpose, we used a computerized image analysis system to study pyramidal cells from the hippocampus of ten AD patients, ten demented schizophrenic (SC) patients and ten cognitively impaired non-AD/non-SC control patients with. We examined cell shape, area and disarray and quantitated the number of SP's and neurofibrillary tangles (NFT's) in the CA1 subfield of the hippocampus. Our results indicated no significant differences between groups for measurements of neuronal shape, size, or disarray. Contrary to earlier reports, our results noted no evidence of pyramidal cell disarray in schizophrenic patients. Our results suggest that SP's incorporate, rather than displace, their surrounding neuropil.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalJournal of Neuroscience Methods
Volume110
Issue number1-2
DOIs
StatePublished - Sep 30 2001

Fingerprint

Amyloid Plaques
Neurons
Pyramidal Cells
Hippocampus
Alzheimer Disease
Neurofibrillary Tangles
Neuropil
Cell Shape

Keywords

  • Alzheimer's disease
  • Hippocampus
  • Pyramidal cells
  • Senile plaques

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Senile plaques exert no mass lesion effect on surrounding neurons. / Casanova, Manuel F.; Hill, William D; Pourdihimi, Benam.

In: Journal of Neuroscience Methods, Vol. 110, No. 1-2, 30.09.2001, p. 125-133.

Research output: Contribution to journalArticle

Casanova, Manuel F. ; Hill, William D ; Pourdihimi, Benam. / Senile plaques exert no mass lesion effect on surrounding neurons. In: Journal of Neuroscience Methods. 2001 ; Vol. 110, No. 1-2. pp. 125-133.
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