Sensitivity and specificity-like measures of the validity of a diagnostic test that are corrected for chance agreement

Steven S. Coughlin, Linda W. Pickle

Research output: Contribution to journalArticle

24 Scopus citations


Chance agreement may account for a sizeable proportion of the specificity of a screening test when the disease prevalence is low. Conversely, the observed sensitivity may be largely accounted for by chance agreement when the prevalence of disease is high. We derive descriptive statistics that are analogous to sensitivity and specificity and corrected for the agreement expected by chance. These coefficients of validity are shown to be dependent on the true prevalence of disease, as well as sensitivity and specificity.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
Issue number2
StatePublished - Mar 1992
Externally publishedYes



  • Biometrics
  • Epidemiologic methods
  • Kappa
  • Screening
  • Sensitivity
  • Specificity
  • Validity

ASJC Scopus subject areas

  • Epidemiology

Cite this