Serendipitous recanalization of basilar artery occlusion

Research output: Contribution to journalArticle

Abstract

Objective To describe a case of recanalization of a basilar artery occlusion with intravenous (IV) tenecteplase. Case A 74-year-old man with a history of cardiomyopathy presented to an outside hospital with acute vertigo, dysarthria, gaze deviation, and ataxia. Computerized tomography arteriography demonstrated occlusion of the proximal basilar artery. IV tissue plasminogen activator was ordered; however, the patient received a cardiac dose of IV tenecteplase. The patient was transferred to our facility, whereby symptoms resolved, and repeat computerized tomography arteriography displayed recanalization of the basilar artery. Conclusions Tenecteplase has enhanced biochemical and pharmacokinetic properties that may be ideal for treatment of basilar artery occlusion and should be further investigated in a randomized clinical trial.

Original languageEnglish (US)
JournalJournal of Stroke and Cerebrovascular Diseases
Volume22
Issue number8
DOIs
StatePublished - Nov 1 2013

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Basilar Artery
Angiography
Tomography
Dysarthria
Vertigo
Tissue Plasminogen Activator
Ataxia
Cardiomyopathies
Randomized Controlled Trials
Pharmacokinetics
tenecteplase
Therapeutics

Keywords

  • Basilar artery occlusion
  • acute stroke
  • tenecteplase
  • thrombolytic therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

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title = "Serendipitous recanalization of basilar artery occlusion",
abstract = "Objective To describe a case of recanalization of a basilar artery occlusion with intravenous (IV) tenecteplase. Case A 74-year-old man with a history of cardiomyopathy presented to an outside hospital with acute vertigo, dysarthria, gaze deviation, and ataxia. Computerized tomography arteriography demonstrated occlusion of the proximal basilar artery. IV tissue plasminogen activator was ordered; however, the patient received a cardiac dose of IV tenecteplase. The patient was transferred to our facility, whereby symptoms resolved, and repeat computerized tomography arteriography displayed recanalization of the basilar artery. Conclusions Tenecteplase has enhanced biochemical and pharmacokinetic properties that may be ideal for treatment of basilar artery occlusion and should be further investigated in a randomized clinical trial.",
keywords = "Basilar artery occlusion, acute stroke, tenecteplase, thrombolytic therapy",
author = "Switzer, {Jeffrey A} and Forseen, {Scott Evan} and Askiel Bruno and Hess, {David C}",
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language = "English (US)",
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AU - Switzer, Jeffrey A

AU - Forseen, Scott Evan

AU - Bruno, Askiel

AU - Hess, David C

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N2 - Objective To describe a case of recanalization of a basilar artery occlusion with intravenous (IV) tenecteplase. Case A 74-year-old man with a history of cardiomyopathy presented to an outside hospital with acute vertigo, dysarthria, gaze deviation, and ataxia. Computerized tomography arteriography demonstrated occlusion of the proximal basilar artery. IV tissue plasminogen activator was ordered; however, the patient received a cardiac dose of IV tenecteplase. The patient was transferred to our facility, whereby symptoms resolved, and repeat computerized tomography arteriography displayed recanalization of the basilar artery. Conclusions Tenecteplase has enhanced biochemical and pharmacokinetic properties that may be ideal for treatment of basilar artery occlusion and should be further investigated in a randomized clinical trial.

AB - Objective To describe a case of recanalization of a basilar artery occlusion with intravenous (IV) tenecteplase. Case A 74-year-old man with a history of cardiomyopathy presented to an outside hospital with acute vertigo, dysarthria, gaze deviation, and ataxia. Computerized tomography arteriography demonstrated occlusion of the proximal basilar artery. IV tissue plasminogen activator was ordered; however, the patient received a cardiac dose of IV tenecteplase. The patient was transferred to our facility, whereby symptoms resolved, and repeat computerized tomography arteriography displayed recanalization of the basilar artery. Conclusions Tenecteplase has enhanced biochemical and pharmacokinetic properties that may be ideal for treatment of basilar artery occlusion and should be further investigated in a randomized clinical trial.

KW - Basilar artery occlusion

KW - acute stroke

KW - tenecteplase

KW - thrombolytic therapy

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