Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: A case report and literature review

Dalia Moghazy, Chakradhari Sharan, Malika Nair, Cassandra Rackauskas, Robert Burnette, Michael Diamond, Omar Al-Hendy, Ayman Al-Hendy

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background: Sertoli-Leydig cell tumor (SLCT) is a rare sex-cord tumor that usually occurs unilaterally and accounts for < 0.5% of all ovarian tumors. SLCT is uncommon in post-menopausal women, with the average age of diagnosis being 25 years.

Case. We present a case of a 63-year-old post-menopausal woman presenting with progressive hirsutism, and male-pattern baldness. Unusual nail changes were also observed.

Methods. Hormonal profile of the patient revealed increased testosterone and estradiol levels, and a 3.5 cm left ovarian mass. The patient was evaluated and was not found to be anemic or iron-deficient. Intraoperative frozen section assessment during laparoscopic exploration revealed SLCT, which was confirmed subsequently by histopathological and immunohistochemical (IHC) examination. Nail bed tissues were collected from normal females and evaluated by IHC for the presence of androgen receptors (AR).

Results: The patient had an excellent postoperative course and all her testosterone-related manifestations were reversed within one year of surgery. Following surgery, the patient's unique nail abnormalities also resolved gradually. The IHC evaluation also confirmed the presence of AR in nail bed tissues of females.

Conclusion: SLCT, albeit rare, should be considered in post-menopausal women presenting with virilization and elevated androgen levels. Unusual nail signs may develop in response to increased androgen levels in these patients.

Original languageEnglish (US)
Article number83
JournalJournal of Ovarian Research
Volume7
Issue number1
DOIs
StatePublished - Aug 28 2014

Fingerprint

Sertoli-Leydig Cell Tumor
Nails
Androgen Receptors
Androgens
Testosterone
Malformed Nails
Virilism
Hirsutism
Alopecia
Frozen Sections
Estradiol
Neoplasms
Iron

Keywords

  • Androgenic nail changes
  • Hirsutism
  • Postmenopausal woman
  • Sertoli-Leydig cell tumor
  • Virilization

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman : A case report and literature review. / Moghazy, Dalia; Sharan, Chakradhari; Nair, Malika; Rackauskas, Cassandra; Burnette, Robert; Diamond, Michael; Al-Hendy, Omar; Al-Hendy, Ayman.

In: Journal of Ovarian Research, Vol. 7, No. 1, 83, 28.08.2014.

Research output: Contribution to journalReview article

Moghazy, Dalia ; Sharan, Chakradhari ; Nair, Malika ; Rackauskas, Cassandra ; Burnette, Robert ; Diamond, Michael ; Al-Hendy, Omar ; Al-Hendy, Ayman. / Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman : A case report and literature review. In: Journal of Ovarian Research. 2014 ; Vol. 7, No. 1.
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