Serum leptin levels are associated with cognitive function in older adults

John Gunstad, Mary Beth Spitznagel, Therese A. Keary, Ellen Glickman, Thomas Alexander, Jessica Karrer, Kelly Stanek, Lynn Reese, Judi Juvancic-Heltzel

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Recent work suggests that leptin, a circulating adipokinine hormone, might contribute to age-related cognitive decline. The present study investigated the relationship between serum leptin levels and cognitive function in older adults. Thirty-five older adults (73.69 ± 6.62 years of age) without significant neurologic or psychiatric history completed a fasting blood draw and a brief neuropsychological test battery. Partial correlations adjusting for demographic and medical conditions showed that higher leptin levels were associated with poorer performance on Trail Making Test B (r=.46, p=.01). These findings indicate that serum leptin levels are negatively associated with speeded executive function in older adults without significant neurological or psychiatric conditions. The mechanisms for this relationship are unknown and require further examination. Such studies may provide key insight into the mechanisms of age-related cognitive decline and identify possible interventions.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalBrain Research
Volume1230
DOIs
StatePublished - Sep 16 2008

Fingerprint

Leptin
Cognition
Serum
Psychiatry
Trail Making Test
Neuropsychological Tests
Executive Function
Nervous System
Fasting
Demography
Hormones
Cognitive Dysfunction

Keywords

  • Cognition
  • Elderly
  • Leptin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Gunstad, J., Spitznagel, M. B., Keary, T. A., Glickman, E., Alexander, T., Karrer, J., ... Juvancic-Heltzel, J. (2008). Serum leptin levels are associated with cognitive function in older adults. Brain Research, 1230, 233-236. https://doi.org/10.1016/j.brainres.2008.07.045

Serum leptin levels are associated with cognitive function in older adults. / Gunstad, John; Spitznagel, Mary Beth; Keary, Therese A.; Glickman, Ellen; Alexander, Thomas; Karrer, Jessica; Stanek, Kelly; Reese, Lynn; Juvancic-Heltzel, Judi.

In: Brain Research, Vol. 1230, 16.09.2008, p. 233-236.

Research output: Contribution to journalArticle

Gunstad, J, Spitznagel, MB, Keary, TA, Glickman, E, Alexander, T, Karrer, J, Stanek, K, Reese, L & Juvancic-Heltzel, J 2008, 'Serum leptin levels are associated with cognitive function in older adults', Brain Research, vol. 1230, pp. 233-236. https://doi.org/10.1016/j.brainres.2008.07.045
Gunstad J, Spitznagel MB, Keary TA, Glickman E, Alexander T, Karrer J et al. Serum leptin levels are associated with cognitive function in older adults. Brain Research. 2008 Sep 16;1230:233-236. https://doi.org/10.1016/j.brainres.2008.07.045
Gunstad, John ; Spitznagel, Mary Beth ; Keary, Therese A. ; Glickman, Ellen ; Alexander, Thomas ; Karrer, Jessica ; Stanek, Kelly ; Reese, Lynn ; Juvancic-Heltzel, Judi. / Serum leptin levels are associated with cognitive function in older adults. In: Brain Research. 2008 ; Vol. 1230. pp. 233-236.
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