SGLT-2 Inhibitors and GLP-1 Agonists: First-Line Therapy for Diabetes With Established Cardiovascular Disease

Aparna P. Sajja, Amit K. Dey, Avirup Guha, Youssef Elnabawi, Aditya A. Joshi, Ankur Kalra

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

There is a growing body of evidence that diabetes represents a significant and largely modifiable risk factor for cardiovascular disease (CVD). It is known to markedly increase the risk of CVD—with CVD accounting for 2 of every 3 deaths in patients with diabetes. It is suggested that once patients with diabetes develop clinical coronary disease, they have a grim prognosis. In 2008, the Food and Drug Association mandated the evidence of CV safety in any new diabetic therapy, leading to a multitude of large CV outcome trials to assess CV risk from these medications. However, several of these outcome trials with novel antidiabetic therapies have demonstrated not only safety but a clear and definite CV advantage in patients with type 2 diabetes. In this review, we discuss 2 relatively newer classes of diabetic drugs, sodium glucose cotransport 2 inhibitors and glucagon-like peptide 1 agonists, evaluate their efficacy in improving CV outcomes, and discuss the future of CV prevention with these agents.
Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2019

Keywords

  • GLP-1 agonists
  • SGLT-2 inhibitors
  • diabetes

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