Should people with a first-degree relative who died from subarachnoid hemorrhage be screened for aneursyms?

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

In a systematic review of 23 studies involving 56,304 patients, the prevalence of ICA varied by the number of family members affected; 2.3% in general population, 4% for 1 primary family member affected, and 8% for 2 or more primary family members affected. The annual rate of rupture in a retrospective study of 1449 patients was 0.5%. Rate of rupture varied based on size of aneurysm, location, and gender. In a more recent case series of relatives of people who suffered an subarachnoid hemorrhage, the absolute lifetime risk of subarachnoid hemorrhage was 4.7% (95% confidence interval [CI], 3.1-6.3%). In a case series of 626 patients having 1 primary relative with ICA, screening with magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) backup resulted in 0.9 months increased life expectancy per person screened, at the cost of 19 years of decreased function. A mathematical model applied to this study showed that surgery improved life expectancy by an average of 2.5 years; a 6-month postoperative functional assessment found functional impairment in 11 of 18 surgical patients (number needed to harm [NNH]=1.6). In a separate study using data from the same population, being a sibling of an ICA sufferer increased risk of ICA (relative risk=3.8, though with a wide 95% CI of 1.1-29.3). Neither hypertension nor hypercholesterolemia conferred increased risk of ICA, and the risk conferred by smoking and use of alcohol was statistically insignificant. In a study of MRA with digital subtraction angiography backup, conducted using theoretical models, screening individuals having 2 or more first-degree relatives with aneurysm would result in severe morbidity or death in 26 individuals per 1000 patients screened, vs 15 per 1000 unscreened individuals over a 30-year period. These results were achieved assuming an ICA prevalence estimate of 9.8%, as determined from an earlier population study of individuals with at least 2 first-degree relatives with ICA. The lower ICA prevalence rate of 4% for patients with only 1 primary affected relative would yield an even more favorable result for not screening. A mathematical model for evaluating cost effectiveness of screening for asymptomatic intracranial aneurysms in the general population determined there is a quality-adjusted life-year reduction for presumed ICA prevalence rates as high as 10%, given an annual rate of rupture of 0.05%. The average cost was $1121 for those who underwent screening vs $147 for those who did not. The presumed variables of prevalence, annual rates of ICA rupture, and surgical mortality and morbidity greatly influenced cost-effectiveness. Screening could be reasonable in populations with higher rupture rates, and if surgical morbidity and mortality decline. Recently, the psychosocial aspects of screening for ICA have been studied. In 1 case series of 105 patients, 35 screen-positive patients scored lower for quality of life than 70 screen-negative patients. However, only 3 patients regretted participating in screening. An observational study of 980 first-degree relatives of patients with subarachnoid hemorrhage determined that offering screening for ICA did not provoke anxiety or depression. Providing thorough counseling before screening can help to alleviate the patient's anxiety.

Original languageEnglish (US)
Pages (from-to)59-60
Number of pages2
JournalJournal of Family Practice
Volume55
Issue number1
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Subarachnoid Hemorrhage
Rupture
Theoretical Models
Population
Magnetic Resonance Angiography
Life Expectancy
Morbidity
Cost-Benefit Analysis
Aneurysm
Anxiety
Confidence Intervals
Digital Subtraction Angiography
Quality-Adjusted Life Years
Mortality
Intracranial Aneurysm
Hypercholesterolemia
Observational Studies
Counseling
Siblings
Retrospective Studies

ASJC Scopus subject areas

  • Family Practice

Cite this

Should people with a first-degree relative who died from subarachnoid hemorrhage be screened for aneursyms? / Jacoby, Geoff; Sams, Richard Woodville.

In: Journal of Family Practice, Vol. 55, No. 1, 01.01.2006, p. 59-60.

Research output: Contribution to journalReview article

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title = "Should people with a first-degree relative who died from subarachnoid hemorrhage be screened for aneursyms?",
abstract = "In a systematic review of 23 studies involving 56,304 patients, the prevalence of ICA varied by the number of family members affected; 2.3{\%} in general population, 4{\%} for 1 primary family member affected, and 8{\%} for 2 or more primary family members affected. The annual rate of rupture in a retrospective study of 1449 patients was 0.5{\%}. Rate of rupture varied based on size of aneurysm, location, and gender. In a more recent case series of relatives of people who suffered an subarachnoid hemorrhage, the absolute lifetime risk of subarachnoid hemorrhage was 4.7{\%} (95{\%} confidence interval [CI], 3.1-6.3{\%}). In a case series of 626 patients having 1 primary relative with ICA, screening with magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) backup resulted in 0.9 months increased life expectancy per person screened, at the cost of 19 years of decreased function. A mathematical model applied to this study showed that surgery improved life expectancy by an average of 2.5 years; a 6-month postoperative functional assessment found functional impairment in 11 of 18 surgical patients (number needed to harm [NNH]=1.6). In a separate study using data from the same population, being a sibling of an ICA sufferer increased risk of ICA (relative risk=3.8, though with a wide 95{\%} CI of 1.1-29.3). Neither hypertension nor hypercholesterolemia conferred increased risk of ICA, and the risk conferred by smoking and use of alcohol was statistically insignificant. In a study of MRA with digital subtraction angiography backup, conducted using theoretical models, screening individuals having 2 or more first-degree relatives with aneurysm would result in severe morbidity or death in 26 individuals per 1000 patients screened, vs 15 per 1000 unscreened individuals over a 30-year period. These results were achieved assuming an ICA prevalence estimate of 9.8{\%}, as determined from an earlier population study of individuals with at least 2 first-degree relatives with ICA. The lower ICA prevalence rate of 4{\%} for patients with only 1 primary affected relative would yield an even more favorable result for not screening. A mathematical model for evaluating cost effectiveness of screening for asymptomatic intracranial aneurysms in the general population determined there is a quality-adjusted life-year reduction for presumed ICA prevalence rates as high as 10{\%}, given an annual rate of rupture of 0.05{\%}. The average cost was $1121 for those who underwent screening vs $147 for those who did not. The presumed variables of prevalence, annual rates of ICA rupture, and surgical mortality and morbidity greatly influenced cost-effectiveness. Screening could be reasonable in populations with higher rupture rates, and if surgical morbidity and mortality decline. Recently, the psychosocial aspects of screening for ICA have been studied. In 1 case series of 105 patients, 35 screen-positive patients scored lower for quality of life than 70 screen-negative patients. However, only 3 patients regretted participating in screening. An observational study of 980 first-degree relatives of patients with subarachnoid hemorrhage determined that offering screening for ICA did not provoke anxiety or depression. Providing thorough counseling before screening can help to alleviate the patient's anxiety.",
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N2 - In a systematic review of 23 studies involving 56,304 patients, the prevalence of ICA varied by the number of family members affected; 2.3% in general population, 4% for 1 primary family member affected, and 8% for 2 or more primary family members affected. The annual rate of rupture in a retrospective study of 1449 patients was 0.5%. Rate of rupture varied based on size of aneurysm, location, and gender. In a more recent case series of relatives of people who suffered an subarachnoid hemorrhage, the absolute lifetime risk of subarachnoid hemorrhage was 4.7% (95% confidence interval [CI], 3.1-6.3%). In a case series of 626 patients having 1 primary relative with ICA, screening with magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) backup resulted in 0.9 months increased life expectancy per person screened, at the cost of 19 years of decreased function. A mathematical model applied to this study showed that surgery improved life expectancy by an average of 2.5 years; a 6-month postoperative functional assessment found functional impairment in 11 of 18 surgical patients (number needed to harm [NNH]=1.6). In a separate study using data from the same population, being a sibling of an ICA sufferer increased risk of ICA (relative risk=3.8, though with a wide 95% CI of 1.1-29.3). Neither hypertension nor hypercholesterolemia conferred increased risk of ICA, and the risk conferred by smoking and use of alcohol was statistically insignificant. In a study of MRA with digital subtraction angiography backup, conducted using theoretical models, screening individuals having 2 or more first-degree relatives with aneurysm would result in severe morbidity or death in 26 individuals per 1000 patients screened, vs 15 per 1000 unscreened individuals over a 30-year period. These results were achieved assuming an ICA prevalence estimate of 9.8%, as determined from an earlier population study of individuals with at least 2 first-degree relatives with ICA. The lower ICA prevalence rate of 4% for patients with only 1 primary affected relative would yield an even more favorable result for not screening. A mathematical model for evaluating cost effectiveness of screening for asymptomatic intracranial aneurysms in the general population determined there is a quality-adjusted life-year reduction for presumed ICA prevalence rates as high as 10%, given an annual rate of rupture of 0.05%. The average cost was $1121 for those who underwent screening vs $147 for those who did not. The presumed variables of prevalence, annual rates of ICA rupture, and surgical mortality and morbidity greatly influenced cost-effectiveness. Screening could be reasonable in populations with higher rupture rates, and if surgical morbidity and mortality decline. Recently, the psychosocial aspects of screening for ICA have been studied. In 1 case series of 105 patients, 35 screen-positive patients scored lower for quality of life than 70 screen-negative patients. However, only 3 patients regretted participating in screening. An observational study of 980 first-degree relatives of patients with subarachnoid hemorrhage determined that offering screening for ICA did not provoke anxiety or depression. Providing thorough counseling before screening can help to alleviate the patient's anxiety.

AB - In a systematic review of 23 studies involving 56,304 patients, the prevalence of ICA varied by the number of family members affected; 2.3% in general population, 4% for 1 primary family member affected, and 8% for 2 or more primary family members affected. The annual rate of rupture in a retrospective study of 1449 patients was 0.5%. Rate of rupture varied based on size of aneurysm, location, and gender. In a more recent case series of relatives of people who suffered an subarachnoid hemorrhage, the absolute lifetime risk of subarachnoid hemorrhage was 4.7% (95% confidence interval [CI], 3.1-6.3%). In a case series of 626 patients having 1 primary relative with ICA, screening with magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) backup resulted in 0.9 months increased life expectancy per person screened, at the cost of 19 years of decreased function. A mathematical model applied to this study showed that surgery improved life expectancy by an average of 2.5 years; a 6-month postoperative functional assessment found functional impairment in 11 of 18 surgical patients (number needed to harm [NNH]=1.6). In a separate study using data from the same population, being a sibling of an ICA sufferer increased risk of ICA (relative risk=3.8, though with a wide 95% CI of 1.1-29.3). Neither hypertension nor hypercholesterolemia conferred increased risk of ICA, and the risk conferred by smoking and use of alcohol was statistically insignificant. In a study of MRA with digital subtraction angiography backup, conducted using theoretical models, screening individuals having 2 or more first-degree relatives with aneurysm would result in severe morbidity or death in 26 individuals per 1000 patients screened, vs 15 per 1000 unscreened individuals over a 30-year period. These results were achieved assuming an ICA prevalence estimate of 9.8%, as determined from an earlier population study of individuals with at least 2 first-degree relatives with ICA. The lower ICA prevalence rate of 4% for patients with only 1 primary affected relative would yield an even more favorable result for not screening. A mathematical model for evaluating cost effectiveness of screening for asymptomatic intracranial aneurysms in the general population determined there is a quality-adjusted life-year reduction for presumed ICA prevalence rates as high as 10%, given an annual rate of rupture of 0.05%. The average cost was $1121 for those who underwent screening vs $147 for those who did not. The presumed variables of prevalence, annual rates of ICA rupture, and surgical mortality and morbidity greatly influenced cost-effectiveness. Screening could be reasonable in populations with higher rupture rates, and if surgical morbidity and mortality decline. Recently, the psychosocial aspects of screening for ICA have been studied. In 1 case series of 105 patients, 35 screen-positive patients scored lower for quality of life than 70 screen-negative patients. However, only 3 patients regretted participating in screening. An observational study of 980 first-degree relatives of patients with subarachnoid hemorrhage determined that offering screening for ICA did not provoke anxiety or depression. Providing thorough counseling before screening can help to alleviate the patient's anxiety.

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