Small GTPase regulation of GPCR anterograde trafficking

Guansong Wang, Guangyu Wu

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalTrends in Pharmacological Sciences
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2012

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Monomeric GTP-Binding Proteins
G-Protein-Coupled Receptors
Endoplasmic Reticulum
Heterotrimeric GTP-Binding Proteins
ras Proteins
GTP Phosphohydrolases
Recycling
Endocytosis
Carrier Proteins
Membrane Proteins

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Small GTPase regulation of GPCR anterograde trafficking. / Wang, Guansong; Wu, Guangyu.

In: Trends in Pharmacological Sciences, Vol. 33, No. 1, 01.01.2012, p. 28-34.

Research output: Contribution to journalReview article

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