Social isolation delays the positive effects of running on adult neurogenesis

Alexis Michelle Stranahan, David Khalil, Elizabeth Gould

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

Social isolation can exacerbate the negative consequences of stress and increase the risk of developing psychopathology. However, the influence of living alone on experiences generally considered to be beneficial to the brain, such as physical exercise, remains unknown. We report here that individual housing precludes the positive influence of short-term running on adult neurogenesis in the hippocampus of rats and, in the presence of additional stress, suppresses the generation of new neurons. Individual housing also influenced corticosterone levels - runners in both housing conditions had elevated corticosterone during the active phase, but individually housed runners had higher levels of this hormone in response to stress. Moreover, lowering corticosterone levels converted the influence of short-term running on neurogenesis in individually housed rats from negative to positive. These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain.

Original languageEnglish (US)
Pages (from-to)526-533
Number of pages8
JournalNature Neuroscience
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Social Isolation
Neurogenesis
Corticosterone
Running
Brain
Interpersonal Relations
Psychopathology
Hippocampus
Hormones
Exercise
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Social isolation delays the positive effects of running on adult neurogenesis. / Stranahan, Alexis Michelle; Khalil, David; Gould, Elizabeth.

In: Nature Neuroscience, Vol. 9, No. 4, 01.04.2006, p. 526-533.

Research output: Contribution to journalArticle

@article{145aa80216c24c1497bf855783cd2a9f,
title = "Social isolation delays the positive effects of running on adult neurogenesis",
abstract = "Social isolation can exacerbate the negative consequences of stress and increase the risk of developing psychopathology. However, the influence of living alone on experiences generally considered to be beneficial to the brain, such as physical exercise, remains unknown. We report here that individual housing precludes the positive influence of short-term running on adult neurogenesis in the hippocampus of rats and, in the presence of additional stress, suppresses the generation of new neurons. Individual housing also influenced corticosterone levels - runners in both housing conditions had elevated corticosterone during the active phase, but individually housed runners had higher levels of this hormone in response to stress. Moreover, lowering corticosterone levels converted the influence of short-term running on neurogenesis in individually housed rats from negative to positive. These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain.",
author = "Stranahan, {Alexis Michelle} and David Khalil and Elizabeth Gould",
year = "2006",
month = "4",
day = "1",
doi = "10.1038/nn1668",
language = "English (US)",
volume = "9",
pages = "526--533",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Social isolation delays the positive effects of running on adult neurogenesis

AU - Stranahan, Alexis Michelle

AU - Khalil, David

AU - Gould, Elizabeth

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Social isolation can exacerbate the negative consequences of stress and increase the risk of developing psychopathology. However, the influence of living alone on experiences generally considered to be beneficial to the brain, such as physical exercise, remains unknown. We report here that individual housing precludes the positive influence of short-term running on adult neurogenesis in the hippocampus of rats and, in the presence of additional stress, suppresses the generation of new neurons. Individual housing also influenced corticosterone levels - runners in both housing conditions had elevated corticosterone during the active phase, but individually housed runners had higher levels of this hormone in response to stress. Moreover, lowering corticosterone levels converted the influence of short-term running on neurogenesis in individually housed rats from negative to positive. These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain.

AB - Social isolation can exacerbate the negative consequences of stress and increase the risk of developing psychopathology. However, the influence of living alone on experiences generally considered to be beneficial to the brain, such as physical exercise, remains unknown. We report here that individual housing precludes the positive influence of short-term running on adult neurogenesis in the hippocampus of rats and, in the presence of additional stress, suppresses the generation of new neurons. Individual housing also influenced corticosterone levels - runners in both housing conditions had elevated corticosterone during the active phase, but individually housed runners had higher levels of this hormone in response to stress. Moreover, lowering corticosterone levels converted the influence of short-term running on neurogenesis in individually housed rats from negative to positive. These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain.

UR - http://www.scopus.com/inward/record.url?scp=33645357517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645357517&partnerID=8YFLogxK

U2 - 10.1038/nn1668

DO - 10.1038/nn1668

M3 - Article

VL - 9

SP - 526

EP - 533

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 4

ER -