Soluble TNF and IL-6 receptors

Indicators of vascular health in women without cardiovascular disease

Miriam Yvette Cortez-Cooper, Eric Meaders, Judith B Stallings, Sara Haddow Liebel, Barbara J Kraj, Gloria Sloan, Kevin K. McCully, Joseph Gerard Cannon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cytokine receptor subunits are released from cells in a regulated manner and circulate in soluble forms at concentrations that are orders of magnitude greater than the concentrations of the cytokines themselves. The purpose of this study was to determine if the circulating concentrations of soluble receptor subunits for interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) might serve as early indicators of vascular dysfunction independent of the traditional cardiovascular disease (CVD) risk factors in women. Healthy women, aged 20-50 years (n = 36), were assessed for circulating concentrations of the cytokines IL-1β, IL-6 and TNFα and the soluble cytokine receptor subunits interleukin-1 receptor type I (sIL-1RI), sIL-1RII, sIL-6Rα, glycoprotein 130 (s-gp130), soluble TNF receptor type 1 (sTNFR1), and sTNFR2, along with traditional CVD risk factors. Cytokine receptor subunit expression on mononuclear cells and the release of these subunits in vitro were also determined. Brachial artery flow-mediated dilation (FMD), carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cfPWV) were assessed by ultrasonography and Doppler probes. Circulating sIL-6Rα correlated negatively with FMD (r = -0.56, p = 0.007) independent of age and other CVD risk factors. Circulating sTNFR1 correlated positively with cfPWV (r = 0.60, p = 0.002). TNFR1 receptor expression on monocytes correlated positively with cIMT (r = 0.51, p = 0.004). Plasma concentrations of IL-1β, IL-6 and TNFα were not significantly associated with FMD, cIMT or cfPWV. These data suggest that the receptors for IL-6 and TNFα, rather than the cytokines themselves, may be better indicators of early vascular changes that are associated with CVD.

Original languageEnglish (US)
Pages (from-to)282-289
Number of pages8
JournalVascular Medicine (United Kingdom)
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2013

Fingerprint

Interleukin-6 Receptors
Women's Health
Blood Vessels
Cardiovascular Diseases
Tumor Necrosis Factor-alpha
Carotid Intima-Media Thickness
Pulse Wave Analysis
Cytokine Receptors
Thigh
Interleukin-1beta
Receptors, Tumor Necrosis Factor, Type I
Dilatation
Interleukin-6
Cytokines
Interleukin-1 Type I Receptors
Cytokine Receptor gp130
Doppler Ultrasonography
Brachial Artery
Tumor Necrosis Factor Receptors
Monocytes

Keywords

  • atherosclerosis
  • cytokines
  • endothelium
  • monocytes
  • vascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Soluble TNF and IL-6 receptors : Indicators of vascular health in women without cardiovascular disease. / Cortez-Cooper, Miriam Yvette; Meaders, Eric; Stallings, Judith B; Liebel, Sara Haddow; Kraj, Barbara J; Sloan, Gloria; McCully, Kevin K.; Cannon, Joseph Gerard.

In: Vascular Medicine (United Kingdom), Vol. 18, No. 5, 01.10.2013, p. 282-289.

Research output: Contribution to journalArticle

Cortez-Cooper, Miriam Yvette ; Meaders, Eric ; Stallings, Judith B ; Liebel, Sara Haddow ; Kraj, Barbara J ; Sloan, Gloria ; McCully, Kevin K. ; Cannon, Joseph Gerard. / Soluble TNF and IL-6 receptors : Indicators of vascular health in women without cardiovascular disease. In: Vascular Medicine (United Kingdom). 2013 ; Vol. 18, No. 5. pp. 282-289.
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