### Abstract

The purpose of this study was to test the null hypothesis that the re-expansion of dried matrix and the shrinkage of moist, demineralized dentin is not influenced by polar solvents. Dentin disks were prepared from mid-coronal dentin of extracted human third molars. After complete demineralization in 0.5M of EDTA (pH 7), the specimens were placed in the well of a device that measures changes in matrix height in real time. Dry, collapsed matrices were created by blowing dry N_{2} on the specimens until they shrank to a stable plateau. Polar solvents [water, methanol, ethanol, n-propanol, n-butanol, formamide, ethylene glycol, hydroxyethyl methacrylate (HEMA), or mixtures of water-HEMA] as model primers then were added and the degree of re-expansion measured. These same solvents also were applied to moist, expanded matrices and the solvent-induced shrinkages measured. Regression analysis was used to test the correlations between matrix height and Hansen's dispersive, polar, hydrogen bonding, and total solubility parameters (δ_{d}, δ_{p}, δ_{h}, δ_{t}). The results indicate that water-free polar solvents of low hydrogen bonding (H-bond) ability (e.g., neat HEMA) do not re-expand dried matrices and that they shrink moist matrices. When HEMA was mixed with progressively higher water concentrations, the model water-HEMA primers expanded the dried matrix in proportion to their water concentrations and they produced less shrinkage of moist matrices. Solvents with higher H-bonding capacities (methanol, ethanol, ethylene glycol, formamide, and water) re-expanded the dried matrix in proportion to their solubility parameters for H-bonding (δ_{h}). They also induced small transient shrinkages of moist matrices, which slowly re-expanded The results require rejection of the null hypothesis.

Original language | English (US) |
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Pages (from-to) | 273-281 |

Number of pages | 9 |

Journal | Journal of Biomedical Materials Research |

Volume | 56 |

Issue number | 2 |

DOIs | |

State | Published - Jun 21 2001 |

### Keywords

- Bioadhesives
- Demineralized dentin
- Model primers
- Solubility parameters

### ASJC Scopus subject areas

- Biomaterials
- Biomedical Engineering

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## Cite this

*Journal of Biomedical Materials Research*,

*56*(2), 273-281. https://doi.org/10.1002/1097-4636(200108)56:2<273::AID-JBM1095>3.0.CO;2-A