TY - JOUR
T1 - STAT3 as a therapeutic target in head and neck cancer
AU - Leeman, Rebecca J.
AU - Lui, Vivian Wai Yan
AU - Grandis, Jennifer Rubin
N1 - Funding Information:
This research was supported by National Institutes of Health grants P50 CA097190-01A1 and R01CA 101840-01 (to JRG).
PY - 2006/3
Y1 - 2006/3
N2 - The signal transducer and activator of transcription (STAT) proteins relay signals from cytokine receptors and receptor tyrosine kinases on the cell surface to the nucleus, where they affect the transcription of genes involved in normal cell functions, including growth, apoptosis and differentiation. STAT3 has been found to be constitutively active in head and neck squamous cell carcinoma (HNSCC) as well as in other epithelial malignancies. In HNSCC, STAT3 alters the cell cycle, prevents apoptosis, and mediates the proliferation and survival of tumour cells. Several therapeutic approaches are being developed to target STAT3, including molecules that block either dimerisation or DNA binding by STAT3, strategies to decrease STAT3 expression and drugs that inhibit STAT3 function. Strategies that block STAT3 may prove efficacious for cancer treatment.
AB - The signal transducer and activator of transcription (STAT) proteins relay signals from cytokine receptors and receptor tyrosine kinases on the cell surface to the nucleus, where they affect the transcription of genes involved in normal cell functions, including growth, apoptosis and differentiation. STAT3 has been found to be constitutively active in head and neck squamous cell carcinoma (HNSCC) as well as in other epithelial malignancies. In HNSCC, STAT3 alters the cell cycle, prevents apoptosis, and mediates the proliferation and survival of tumour cells. Several therapeutic approaches are being developed to target STAT3, including molecules that block either dimerisation or DNA binding by STAT3, strategies to decrease STAT3 expression and drugs that inhibit STAT3 function. Strategies that block STAT3 may prove efficacious for cancer treatment.
KW - Head and neck cancer
KW - STAT3 inhibitors
KW - STAT3 targeted therapy
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U2 - 10.1517/14712598.6.3.231
DO - 10.1517/14712598.6.3.231
M3 - Review article
C2 - 16503733
AN - SCOPUS:33644773438
SN - 1471-2598
VL - 6
SP - 231
EP - 241
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
IS - 3
ER -
