Stem cell-derived exosomes

A potential alternative therapeutic agent in orthopaedics

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics.

Original languageEnglish (US)
Article number5802529
JournalStem Cells International
Volume2016
DOIs
StatePublished - Jan 1 2016

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Exosomes
Orthopedics
Stem Cells
Regenerative Medicine
Therapeutics
Bone Fractures
MicroRNAs
Osteoarthritis
Rheumatoid Arthritis
Medicine

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

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title = "Stem cell-derived exosomes: A potential alternative therapeutic agent in orthopaedics",
abstract = "Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics.",
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AU - Burke, John

AU - Kolhe, Ravindra Bharat

AU - Hunter, David M

AU - Isales, Carlos M

AU - Hamrick, Mark W

AU - Fulzele, Sadanand T

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