Stem Cell Therapy in Cerebrovascular Disease

Michael I. Nahhas, David C. Hess

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Purpose of review: The purpose of this article is to provide a review of state-of-the-art cellular therapy in cerebrovascular diseases by discussing published and ongoing clinical trials. Recent findings: In spite of the challenge in translating the success of cellular therapy in acute strokes from preclinical models to clinical trials, early phase clinical trial have recently shown promise in overcoming these challenges. Various stem cell types and doses are being studied, different routes of administration are under investigation, as well as defining the optimal time window to intervene. In addition, experimental methods to enhance cellular therapy, such as ischemic preconditioning, are evolving. Summary: After the failure of neuroprotectants in cerebrovascular diseases, researchers have been keen to provide a way of replacement of damaged brain tissue and to promote recovery in order to achieve better outcomes. The field has progressed from intravenous delivery in the 24- to 36-h time window to later intracerebral administration in chronic stroke in clinical trials. New optimism in acute stroke care fostered by the success of mechanical thrombectomy will hopefully extend into cell therapy to promote recovery.

Original languageEnglish (US)
Article number49
JournalCurrent Treatment Options in Neurology
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2018

Keywords

  • Cell therapy
  • Exosomes
  • Ischemic stroke
  • Stem cells

ASJC Scopus subject areas

  • Clinical Neurology

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