Steroid compounds of marine sponges. VII. Preparation of derivatives of sokotrasterol and halistanol sulfates and structure-activity interrelationships among these compounds

T. N. Makar'eva, I. A. Gorshkova, Boris A Gorshkov, A. I. Kalinovskii, V. A. Stonik

Research output: Contribution to journalArticle

Abstract

Five new sulfated derivatives of sokotrasterol and halistanol have been obtained: 24-nor-5α-cholane-2β,3α,6α,23-tetraol 2β,3α,6α-tri(sodium sulfate); 24-nor-5α-cholane-2β,3α,6α,23-tetraol 2β,3α,6α-tri(sodium sulfate) 23-palmitate; 24ε,25-dimethyl-5α-cholestane-2β,3α,6α-triol 3α-(sodium sulfate); 24ε,25-dimethyl-5α-cholestane-2β,3α,6α-triol 6α-(sodium sulfate); and 24ε,25-dimethyl-5α-cholestane-2β,3α,6α-triol 2β,6α-di(sodium sulfate). The inhibiting and membranolytic properties of the polysulfated steroids from sponges and their derivatives have been studied. It has been shown that physiological activity in this series of compounds depends on biphilicity.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalChemistry of Natural Compounds
Volume22
Issue number4
DOIs
StatePublished - Jul 1 1986

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sodium sulfate
Porifera
steroids
Cholestanes
sulfates
Cholanes
Steroids
Derivatives
Palmitates
palmitates
halistanol trisulfate
sokotrasterol sulfate

ASJC Scopus subject areas

  • Plant Science

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Steroid compounds of marine sponges. VII. Preparation of derivatives of sokotrasterol and halistanol sulfates and structure-activity interrelationships among these compounds. / Makar'eva, T. N.; Gorshkova, I. A.; Gorshkov, Boris A; Kalinovskii, A. I.; Stonik, V. A.

In: Chemistry of Natural Compounds, Vol. 22, No. 4, 01.07.1986, p. 411-415.

Research output: Contribution to journalArticle

Makar'eva, T. N. ; Gorshkova, I. A. ; Gorshkov, Boris A ; Kalinovskii, A. I. ; Stonik, V. A. / Steroid compounds of marine sponges. VII. Preparation of derivatives of sokotrasterol and halistanol sulfates and structure-activity interrelationships among these compounds. In: Chemistry of Natural Compounds. 1986 ; Vol. 22, No. 4. pp. 411-415.
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