Steroid, follicle-stimulating hormone, and luteinizing hormone profiles in identical twins with polycystic ovaries

Paul G McDonough, Virendra B. Mahesh, James O. Ellegood

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Identical twins (age 16) with polycystic ovarian disease documented by laparoscopy are compared to a "normal" 18-year-old sibling. Fractionation and individual estimation of urinary 17-ketosteroids, 17-ketogenic steroids, pregnanetriol, and total estrogen were performed on both amenorrheic twins and their normal menstruating sibling. Steroid values were obtained during adrenal suppression and after adrenal provocation with adrenocorticotropic hormone nd metyrapone. Serum levels for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were obtained periodically over a period of 16 months on the twins with polycystic ovarian disease. All 3 siblings gave evidence of androgen overproduction on the part of the ovaries and adrenals. Serum LH values in the twins were elevated but exhibited considerable fluctuation. Serum FSH values were lower but also manifested considerable variation. The similar steroid profile in the 3 siblings and the LH/FSH pattern in the identical twins are discussed.

Original languageEnglish (US)
Pages (from-to)1072-1078
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume113
Issue number8
DOIs
StatePublished - Aug 15 1972

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Monozygotic Twins
Follicle Stimulating Hormone
Luteinizing Hormone
Siblings
Ovary
Steroids
Ovarian Diseases
Pregnanetriol
Serum
17-Ketosteroids
Metyrapone
Laparoscopy
Adrenocorticotropic Hormone
Androgens
Estrogens

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Steroid, follicle-stimulating hormone, and luteinizing hormone profiles in identical twins with polycystic ovaries. / McDonough, Paul G; Mahesh, Virendra B.; Ellegood, James O.

In: American Journal of Obstetrics and Gynecology, Vol. 113, No. 8, 15.08.1972, p. 1072-1078.

Research output: Contribution to journalArticle

McDonough, Paul G ; Mahesh, Virendra B. ; Ellegood, James O. / Steroid, follicle-stimulating hormone, and luteinizing hormone profiles in identical twins with polycystic ovaries. In: American Journal of Obstetrics and Gynecology. 1972 ; Vol. 113, No. 8. pp. 1072-1078.
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