Strategies to promote donor cell survival: Combining preconditioning approach with stem cell transplantation

Husnain Kh Haider, Muhammad Ashraf

Research output: Contribution to journalReview article

153 Scopus citations

Abstract

Stem cell transplantation has emerged as a potential modality in cardiovascular therapeutics due to their inherent characteristics of self-renewal, unlimited capacity for proliferation and ability to cross lineage restrictions and adopt different phenotypes. Constrained by extensive death in the unfriendly milieu of ischemic myocardium, the results of heart cell therapy in experimental animal models as well as clinical studies have been less than optimal. Several factors which play a role in early cell death after engraftment in the ischemic myocardium include: absence of survival factors in the transplanted heart, disruption of cell-cell interaction coupled with loss of survival signals from matrix attachments, insufficient vascular supply and elaboration of inflammatory cytokines resulting from ischemia and/or cell death. This article reviews various signaling pathways involved in triggering highly complex forms of cell death and provides critical appreciation of different novel anti-death strategies developed from the knowledge gained from using an ischemic preconditioning approach. The use of pharmacological preconditioning for up-regulation of pro-survival proteins and cardiogenic markers in the transplanted stem cells will be discussed.

Original languageEnglish (US)
Pages (from-to)554-566
Number of pages13
JournalJournal of molecular and cellular cardiology
Volume45
Issue number4
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

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Keywords

  • Apoptosis
  • Cell
  • Heart
  • Infarction
  • Myocardium
  • Survival
  • Transplantation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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