Successful completion of pregnancy in a patient with chronic myeloid leukemia without active intervention: a case report and review of the literature.

Suzanne Cole, Hagop Kantarjian, Patricia Ault, Jorge E. Cortés

Research output: Contribution to journalArticle

Abstract

The management of patients with chronic myeloid leukemia (CML) during pregnancy is a matter of continued debate. We present a 21-year-old woman in whom CML was diagnosed during early pregnancy. Because the patient was asymptomatic and desired to carry the pregnancy to term while minimizing fetal exposure to medication, she was observed with no therapy for the duration of her pregnancy. The white blood cell count showed a slow downward trend throughout her pregnancy. She delivered a healthy baby and breast fed for a time before initiating therapy for CML. We reviewed the published case reports of women who had a pregnancy occur in the setting of treatment with imatinib. Given the adverse effects of fetal exposure to imatinib as treatment for the mother with CML, close observation might be an option for selected patients who are diagnosed with CML while pregnant and who have minimal clinical manifestations of CML.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalClinical lymphoma & myeloma
Volume9
Issue number4
DOIs
StatePublished - Aug 2009
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pregnancy
Therapeutics
Leukocyte Count
Breast
Mothers
Observation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Successful completion of pregnancy in a patient with chronic myeloid leukemia without active intervention : a case report and review of the literature. / Cole, Suzanne; Kantarjian, Hagop; Ault, Patricia; Cortés, Jorge E.

In: Clinical lymphoma & myeloma, Vol. 9, No. 4, 08.2009, p. 324-327.

Research output: Contribution to journalArticle

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