Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate

Elias Jabbour, Hagop Kantarjian, Susan O'Brien, Mary Beth Rios, Lynne Abruzzo, Srdan Verstovsek, Guillermo Garcia-Manero, Jorge Cortes

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Sudden blastic transformation (SBT) has been reported in 0.5% to 2.5% of patients treated with interferon-α (IFN-α) during the first 3 years of therapy. Imatinib is now standard therapy for patients with chronic myeloid leukemia in chronic phase. We investigated the occurrence of SBT among patients treated with imatinib. Among 541 patients treated with imatinib in chronic phase, 23 developed blast phase, which was of sudden onset (ie, occurring in patients previously in complete cytogenetic remission) in 4 patients (17%; 0.7% of the total), 2 lymphoid and 2 myeloid. Patients with SBT were found to have low-risk features more often at the time of presentation and had achieved optimal response with imatinib. Three of the 4 patients underwent allogeneic stem cell transplantation and achieved a molecular remission. SBT is still a rare event, probably less common than that observed with IFN-α therapy. Continuous monitoring of patients treated with imatinib is mandatory.

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalBlood
Volume107
Issue number2
DOIs
StatePublished - Jan 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Jabbour, E., Kantarjian, H., O'Brien, S., Rios, M. B., Abruzzo, L., Verstovsek, S., Garcia-Manero, G., & Cortes, J. (2006). Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate. Blood, 107(2), 480-482. https://doi.org/10.1182/blood-2005-05-1816