SU‐E‐J‐131

Investigation of Inter‐Fraction Organ Motions for Patients with Pancreatic Cancer

A. Amoush, P. Xia, M. Abdel‐wahab

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the inter‐fractional pancreatic and right kidney motions for patients with pancreatic tumors using daily KV‐CBCTs, acquired prior to each treatment. Materials:Five patients with pancreatic adenocarcinoma, who had the stent placements and received IMRT with daily KV‐CBCT, were selected for this study. Five weekly CBCTs were input to the Pinnacle treatment planning system and aligned with the planning CT (pCT) with the three different registration methods to investigate inter‐fractional organ motions. For each patient, a triple imaging registration was performed, (a) bone‐based registration; (2) right‐kidney based registration; (3) marker‐based registration; Subtracting shifts of the latter two registrations from the bone registration, we obtained the interfraction motions for the pancreas and the right kidney. The CTV contours on the CBCTs were transferred from the pCT by using a point‐based registration. The right kidney contours on the CBCTs were manually defined. Subsequently, IMRT plans were applied to these CBCTs with the iso‐center shifted according to the different registration methods. Dose calculations on the CBCT were set to a density of 1 g/cc. The CTV receiving 95% of the prescription dose (V95%) and the mean dose to the right kidney were evaluated. Results: A total of 25 CBCT images were analyzed. The average kidney‐motion was 3.58±0.43 mm, 2.08±0.36 mm, and 5.94±0.87 mm in the lateral, vertical and longitudinal directions, respectively. The CTV motion was 5.09±0.31 mm, 2.75±0.17 mm, and 7.80±0.92 mm, respectively. V95% of the CTV was 95.65±5.46 %, and 94±11.47 % for the bone‐based registration and marker‐based registrations, respectively. The mean dose of the right kidney was 6.16±1.87 Gy and 7.48±2.96 Gy, respectively. Conclusions:The CTV V95% is comparable between bone‐registration and marker‐based registration and the mean dose to the right kidney is well below the tolerance. Update results from more patients and more daily CBCTs will be reported.

Original languageEnglish (US)
Pages (from-to)181
Number of pages1
JournalMedical Physics
Volume40
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Pancreatic Neoplasms
Kidney
Stents
Prescriptions
Pancreas
Adenocarcinoma
Bone and Bones
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

SU‐E‐J‐131 : Investigation of Inter‐Fraction Organ Motions for Patients with Pancreatic Cancer. / Amoush, A.; Xia, P.; Abdel‐wahab, M.

In: Medical Physics, Vol. 40, No. 6, 2013, p. 181.

Research output: Contribution to journalArticle

Amoush, A. ; Xia, P. ; Abdel‐wahab, M. / SU‐E‐J‐131 : Investigation of Inter‐Fraction Organ Motions for Patients with Pancreatic Cancer. In: Medical Physics. 2013 ; Vol. 40, No. 6. pp. 181.
@article{6a833d6b6fe345a4a2f954a88dbbd4c2,
title = "SU‐E‐J‐131: Investigation of Inter‐Fraction Organ Motions for Patients with Pancreatic Cancer",
abstract = "Purpose: To investigate the inter‐fractional pancreatic and right kidney motions for patients with pancreatic tumors using daily KV‐CBCTs, acquired prior to each treatment. Materials:Five patients with pancreatic adenocarcinoma, who had the stent placements and received IMRT with daily KV‐CBCT, were selected for this study. Five weekly CBCTs were input to the Pinnacle treatment planning system and aligned with the planning CT (pCT) with the three different registration methods to investigate inter‐fractional organ motions. For each patient, a triple imaging registration was performed, (a) bone‐based registration; (2) right‐kidney based registration; (3) marker‐based registration; Subtracting shifts of the latter two registrations from the bone registration, we obtained the interfraction motions for the pancreas and the right kidney. The CTV contours on the CBCTs were transferred from the pCT by using a point‐based registration. The right kidney contours on the CBCTs were manually defined. Subsequently, IMRT plans were applied to these CBCTs with the iso‐center shifted according to the different registration methods. Dose calculations on the CBCT were set to a density of 1 g/cc. The CTV receiving 95{\%} of the prescription dose (V95{\%}) and the mean dose to the right kidney were evaluated. Results: A total of 25 CBCT images were analyzed. The average kidney‐motion was 3.58±0.43 mm, 2.08±0.36 mm, and 5.94±0.87 mm in the lateral, vertical and longitudinal directions, respectively. The CTV motion was 5.09±0.31 mm, 2.75±0.17 mm, and 7.80±0.92 mm, respectively. V95{\%} of the CTV was 95.65±5.46 {\%}, and 94±11.47 {\%} for the bone‐based registration and marker‐based registrations, respectively. The mean dose of the right kidney was 6.16±1.87 Gy and 7.48±2.96 Gy, respectively. Conclusions:The CTV V95{\%} is comparable between bone‐registration and marker‐based registration and the mean dose to the right kidney is well below the tolerance. Update results from more patients and more daily CBCTs will be reported.",
author = "A. Amoush and P. Xia and M. Abdel‐wahab",
year = "2013",
doi = "10.1118/1.4814343",
language = "English (US)",
volume = "40",
pages = "181",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "6",

}

TY - JOUR

T1 - SU‐E‐J‐131

T2 - Investigation of Inter‐Fraction Organ Motions for Patients with Pancreatic Cancer

AU - Amoush, A.

AU - Xia, P.

AU - Abdel‐wahab, M.

PY - 2013

Y1 - 2013

N2 - Purpose: To investigate the inter‐fractional pancreatic and right kidney motions for patients with pancreatic tumors using daily KV‐CBCTs, acquired prior to each treatment. Materials:Five patients with pancreatic adenocarcinoma, who had the stent placements and received IMRT with daily KV‐CBCT, were selected for this study. Five weekly CBCTs were input to the Pinnacle treatment planning system and aligned with the planning CT (pCT) with the three different registration methods to investigate inter‐fractional organ motions. For each patient, a triple imaging registration was performed, (a) bone‐based registration; (2) right‐kidney based registration; (3) marker‐based registration; Subtracting shifts of the latter two registrations from the bone registration, we obtained the interfraction motions for the pancreas and the right kidney. The CTV contours on the CBCTs were transferred from the pCT by using a point‐based registration. The right kidney contours on the CBCTs were manually defined. Subsequently, IMRT plans were applied to these CBCTs with the iso‐center shifted according to the different registration methods. Dose calculations on the CBCT were set to a density of 1 g/cc. The CTV receiving 95% of the prescription dose (V95%) and the mean dose to the right kidney were evaluated. Results: A total of 25 CBCT images were analyzed. The average kidney‐motion was 3.58±0.43 mm, 2.08±0.36 mm, and 5.94±0.87 mm in the lateral, vertical and longitudinal directions, respectively. The CTV motion was 5.09±0.31 mm, 2.75±0.17 mm, and 7.80±0.92 mm, respectively. V95% of the CTV was 95.65±5.46 %, and 94±11.47 % for the bone‐based registration and marker‐based registrations, respectively. The mean dose of the right kidney was 6.16±1.87 Gy and 7.48±2.96 Gy, respectively. Conclusions:The CTV V95% is comparable between bone‐registration and marker‐based registration and the mean dose to the right kidney is well below the tolerance. Update results from more patients and more daily CBCTs will be reported.

AB - Purpose: To investigate the inter‐fractional pancreatic and right kidney motions for patients with pancreatic tumors using daily KV‐CBCTs, acquired prior to each treatment. Materials:Five patients with pancreatic adenocarcinoma, who had the stent placements and received IMRT with daily KV‐CBCT, were selected for this study. Five weekly CBCTs were input to the Pinnacle treatment planning system and aligned with the planning CT (pCT) with the three different registration methods to investigate inter‐fractional organ motions. For each patient, a triple imaging registration was performed, (a) bone‐based registration; (2) right‐kidney based registration; (3) marker‐based registration; Subtracting shifts of the latter two registrations from the bone registration, we obtained the interfraction motions for the pancreas and the right kidney. The CTV contours on the CBCTs were transferred from the pCT by using a point‐based registration. The right kidney contours on the CBCTs were manually defined. Subsequently, IMRT plans were applied to these CBCTs with the iso‐center shifted according to the different registration methods. Dose calculations on the CBCT were set to a density of 1 g/cc. The CTV receiving 95% of the prescription dose (V95%) and the mean dose to the right kidney were evaluated. Results: A total of 25 CBCT images were analyzed. The average kidney‐motion was 3.58±0.43 mm, 2.08±0.36 mm, and 5.94±0.87 mm in the lateral, vertical and longitudinal directions, respectively. The CTV motion was 5.09±0.31 mm, 2.75±0.17 mm, and 7.80±0.92 mm, respectively. V95% of the CTV was 95.65±5.46 %, and 94±11.47 % for the bone‐based registration and marker‐based registrations, respectively. The mean dose of the right kidney was 6.16±1.87 Gy and 7.48±2.96 Gy, respectively. Conclusions:The CTV V95% is comparable between bone‐registration and marker‐based registration and the mean dose to the right kidney is well below the tolerance. Update results from more patients and more daily CBCTs will be reported.

UR - http://www.scopus.com/inward/record.url?scp=85024785787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024785787&partnerID=8YFLogxK

U2 - 10.1118/1.4814343

DO - 10.1118/1.4814343

M3 - Article

VL - 40

SP - 181

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 6

ER -