1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates

Peter F Buckley, Constance Moore, Helen Long, Conall Larkin, Paul Thompson, Fiona Mulvany, Oonagh Redmond, John P. Stack, Joseph T. Ennis, John L. Waddington

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Twenty eight schizophrenic patients and 20 normal volunteers underwent proton magnetic resonance spectroscopy (MRS) on the left temporal and frontal lobe regions. Male patients showed a significant reduction in frontal but not temporal n-acetylaspartate (an intraneuronally distributed metabolite) in comparison with either male controls or female patients; frontal choline was raised in male patients relative to these groups. Putative neurodevelopmental indices, including obstetric complications, family history of schizophrenia, and minor physical anomalies, proved unrelated to MRS resonances. However, multiple aspects of memory function in patients were related to temporal but not frontal creatine, a pattern that was not apparent among controls. These MRS findings complement some previous structural MRI studies and much clinical and epidemiological evidence of important gender differences in schizophrenia. The findings also suggest that memory dysfunction in patients with schizophrenia may be associated with a particular pattern of temporal lobe metabolism on MRS.

Original languageEnglish (US)
Pages (from-to)792-800
Number of pages9
JournalBiological Psychiatry
Volume36
Issue number12
DOIs
StatePublished - Dec 15 1994

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Frontal Lobe
Temporal Lobe
Schizophrenia
Magnetic Resonance Spectroscopy
Creatine
Choline
Obstetrics
Epidemiologic Studies
Healthy Volunteers

Keywords

  • H-Magnetic resonance spectroscopy
  • cognition
  • neurodevelopment
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia : Clinical, neurodevelopmental, and cognitive correlates. / Buckley, Peter F; Moore, Constance; Long, Helen; Larkin, Conall; Thompson, Paul; Mulvany, Fiona; Redmond, Oonagh; Stack, John P.; Ennis, Joseph T.; Waddington, John L.

In: Biological Psychiatry, Vol. 36, No. 12, 15.12.1994, p. 792-800.

Research output: Contribution to journalArticle

Buckley, PF, Moore, C, Long, H, Larkin, C, Thompson, P, Mulvany, F, Redmond, O, Stack, JP, Ennis, JT & Waddington, JL 1994, '1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates', Biological Psychiatry, vol. 36, no. 12, pp. 792-800. https://doi.org/10.1016/0006-3223(94)90591-6
Buckley, Peter F ; Moore, Constance ; Long, Helen ; Larkin, Conall ; Thompson, Paul ; Mulvany, Fiona ; Redmond, Oonagh ; Stack, John P. ; Ennis, Joseph T. ; Waddington, John L. / 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia : Clinical, neurodevelopmental, and cognitive correlates. In: Biological Psychiatry. 1994 ; Vol. 36, No. 12. pp. 792-800.
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