Surgical Pathology of Pure Aortic Insufficiency

A Study of 225 Gases

LYLE J. OLSON, Ramiah Subramanian, WILLIAM D. EDWARDS

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

The gross surgical pathologic features of the aortic valve were reviewed in 225 patients who had had clinically pure aortic insufficiency and aortic valve replacement at our institution during the years 1965,1970,1975, and 1980. The four most common causes of aortic regurgitation were postinflammatory disease (46%), aortic root dilatation (21%), incomplete closure of a congenitally bicuspid aortic valve (20%), and infective endocarditis (9%). Other causes of aortic incompetence in our study included ventricular septal defects (2%) and quadricuspid aortic valves (1 %); the cause was indeterminate in 1 %. The mean age of patients at valve replacement was approximately 50 years for all etiologic factors except a ventricular septal defect. All forms of aortic insufficiency were much more common in male than in female patients, except the postinflammatory and indeterminate types, which occurred approximately equally in both sexes. Moreover, the incidences of postinflammatory disease and aortic root dilatation changed appreciably with time. Before 1980, their incidences were 51% and 17%, respectively, but during 1980, they were 29% and 37%, respectively. Accordingly, aortic root dilatation is now the most common cause of pure aortic regurgitation in our surgical population. The decrease in the incidence of postinflammatory disease may be a result of the decreasing incidence of acute rheumatic fever reported in western countries.

Original languageEnglish (US)
Pages (from-to)835-841
Number of pages7
JournalMayo Clinic Proceedings
Volume59
Issue number11-12
DOIs
StatePublished - Jan 1 1984

Fingerprint

Surgical Pathology
Aortic Valve Insufficiency
Gases
Dilatation
Aortic Diseases
Ventricular Heart Septal Defects
Incidence
Aortic Valve
Rheumatic Fever
Endocarditis
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Surgical Pathology of Pure Aortic Insufficiency : A Study of 225 Gases. / OLSON, LYLE J.; Subramanian, Ramiah; EDWARDS, WILLIAM D.

In: Mayo Clinic Proceedings, Vol. 59, No. 11-12, 01.01.1984, p. 835-841.

Research output: Contribution to journalArticle

OLSON, LYLEJ, Subramanian, R & EDWARDS, WILLIAMD 1984, 'Surgical Pathology of Pure Aortic Insufficiency: A Study of 225 Gases', Mayo Clinic Proceedings, vol. 59, no. 11-12, pp. 835-841. https://doi.org/10.1016/S0025-6196(12)65618-3
OLSON, LYLE J. ; Subramanian, Ramiah ; EDWARDS, WILLIAM D. / Surgical Pathology of Pure Aortic Insufficiency : A Study of 225 Gases. In: Mayo Clinic Proceedings. 1984 ; Vol. 59, No. 11-12. pp. 835-841.
@article{b8d36a69b09d4fea9981240fba5fdf86,
title = "Surgical Pathology of Pure Aortic Insufficiency: A Study of 225 Gases",
abstract = "The gross surgical pathologic features of the aortic valve were reviewed in 225 patients who had had clinically pure aortic insufficiency and aortic valve replacement at our institution during the years 1965,1970,1975, and 1980. The four most common causes of aortic regurgitation were postinflammatory disease (46{\%}), aortic root dilatation (21{\%}), incomplete closure of a congenitally bicuspid aortic valve (20{\%}), and infective endocarditis (9{\%}). Other causes of aortic incompetence in our study included ventricular septal defects (2{\%}) and quadricuspid aortic valves (1 {\%}); the cause was indeterminate in 1 {\%}. The mean age of patients at valve replacement was approximately 50 years for all etiologic factors except a ventricular septal defect. All forms of aortic insufficiency were much more common in male than in female patients, except the postinflammatory and indeterminate types, which occurred approximately equally in both sexes. Moreover, the incidences of postinflammatory disease and aortic root dilatation changed appreciably with time. Before 1980, their incidences were 51{\%} and 17{\%}, respectively, but during 1980, they were 29{\%} and 37{\%}, respectively. Accordingly, aortic root dilatation is now the most common cause of pure aortic regurgitation in our surgical population. The decrease in the incidence of postinflammatory disease may be a result of the decreasing incidence of acute rheumatic fever reported in western countries.",
author = "OLSON, {LYLE J.} and Ramiah Subramanian and EDWARDS, {WILLIAM D.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1016/S0025-6196(12)65618-3",
language = "English (US)",
volume = "59",
pages = "835--841",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "11-12",

}

TY - JOUR

T1 - Surgical Pathology of Pure Aortic Insufficiency

T2 - A Study of 225 Gases

AU - OLSON, LYLE J.

AU - Subramanian, Ramiah

AU - EDWARDS, WILLIAM D.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - The gross surgical pathologic features of the aortic valve were reviewed in 225 patients who had had clinically pure aortic insufficiency and aortic valve replacement at our institution during the years 1965,1970,1975, and 1980. The four most common causes of aortic regurgitation were postinflammatory disease (46%), aortic root dilatation (21%), incomplete closure of a congenitally bicuspid aortic valve (20%), and infective endocarditis (9%). Other causes of aortic incompetence in our study included ventricular septal defects (2%) and quadricuspid aortic valves (1 %); the cause was indeterminate in 1 %. The mean age of patients at valve replacement was approximately 50 years for all etiologic factors except a ventricular septal defect. All forms of aortic insufficiency were much more common in male than in female patients, except the postinflammatory and indeterminate types, which occurred approximately equally in both sexes. Moreover, the incidences of postinflammatory disease and aortic root dilatation changed appreciably with time. Before 1980, their incidences were 51% and 17%, respectively, but during 1980, they were 29% and 37%, respectively. Accordingly, aortic root dilatation is now the most common cause of pure aortic regurgitation in our surgical population. The decrease in the incidence of postinflammatory disease may be a result of the decreasing incidence of acute rheumatic fever reported in western countries.

AB - The gross surgical pathologic features of the aortic valve were reviewed in 225 patients who had had clinically pure aortic insufficiency and aortic valve replacement at our institution during the years 1965,1970,1975, and 1980. The four most common causes of aortic regurgitation were postinflammatory disease (46%), aortic root dilatation (21%), incomplete closure of a congenitally bicuspid aortic valve (20%), and infective endocarditis (9%). Other causes of aortic incompetence in our study included ventricular septal defects (2%) and quadricuspid aortic valves (1 %); the cause was indeterminate in 1 %. The mean age of patients at valve replacement was approximately 50 years for all etiologic factors except a ventricular septal defect. All forms of aortic insufficiency were much more common in male than in female patients, except the postinflammatory and indeterminate types, which occurred approximately equally in both sexes. Moreover, the incidences of postinflammatory disease and aortic root dilatation changed appreciably with time. Before 1980, their incidences were 51% and 17%, respectively, but during 1980, they were 29% and 37%, respectively. Accordingly, aortic root dilatation is now the most common cause of pure aortic regurgitation in our surgical population. The decrease in the incidence of postinflammatory disease may be a result of the decreasing incidence of acute rheumatic fever reported in western countries.

UR - http://www.scopus.com/inward/record.url?scp=0021750910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021750910&partnerID=8YFLogxK

U2 - 10.1016/S0025-6196(12)65618-3

DO - 10.1016/S0025-6196(12)65618-3

M3 - Article

VL - 59

SP - 835

EP - 841

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 11-12

ER -